Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …

Abstract Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological
functions and pathological significances and play an important role in health and disease. In …

Recent advances in immunometabolism link metabolic changes in stimulated macrophages
to production of IL-1β, a crucial cytokine in the innate immune response to Mycobacterium …

By virtue of their position at the crossroads between the innate and adaptive immune
response, macrophages play an essential role in the control of bacterial infections …

Microtubules play critical roles in regulating the activation of NLRP3 inflammasome and
microtubule-destabilizing agents such as colchicine have been shown to suppress the …

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by
recurrent abscesses, nodules, and sinus tracts in areas of high hair follicle and sweat gland …

Inflammation crucially drives atherosclerosis from disease initiation to the emergence of
clinical complications. Targeting pivotal inflammatory pathways without compromising the …

Immune checkpoint inhibitors (ICIs) have become a promising therapeutic strategy for
malignant tumors, improving patient prognosis, along with a spectrum of immune-related …

Tuberculosis is the single biggest infectious killer in the world and presents a major global
health challenge. Antimicrobial therapy requires many months of multiple drugs and …

Background Circulating monocytes are functionally heterogeneous and can be divided into
classical (CMo), intermediate (IMo), and non-CMo/patrolling monocyte (PMo) subsets. CMo …