Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities

Z Cheng, A Al Zaki, JZ Hui, VR Muzykantov, A Tsourkas - Science, 2012 - science.org
Nanoparticle-based drug delivery systems have been developed to improve the efficacy and
reduce the systemic toxicity of a wide range of drugs. Although clinically approved …

Pearls and pitfalls in clinical interpretation of prostate-specific membrane antigen (PSMA)-targeted PET imaging

S Sheikhbahaei, A Afshar-Oromieh, M Eiber… - European journal of …, 2017 - Springer
Background The rapidly expanding clinical adaptation of prostate-specific membrane
antigen (PSMA)-targeted PET imaging in the evaluation of patients with prostate cancer has …

Diagnostic performance of 68Ga-PSMA-11 (HBED-CC) PET/CT in patients with recurrent prostate cancer: evaluation in 1007 patients

A Afshar-Oromieh, T Holland-Letz, FL Giesel… - European journal of …, 2017 - Springer
Purpose Since the clinical introduction of 68 Ga-PSMA-11 PET/CT, this imaging method has
rapidly spread and is now regarded as a significant step forward in the diagnosis of …

The diagnostic value of PET/CT imaging with the 68Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer

A Afshar-Oromieh, E Avtzi, FL Giesel… - European journal of …, 2015 - Springer
Purpose Since the introduction of positron emission tomography (PET) imaging with 68 Ga-
PSMA-HBED-CC (= 68 Ga-DKFZ-PSMA-11), this method has been regarded as a significant …

The rise of PSMA ligands for diagnosis and therapy of prostate cancer

A Afshar-Oromieh, JW Babich… - Journal of Nuclear …, 2016 - Soc Nuclear Med
The prostate-specific membrane antigen (PSMA) has received increased consideration
during the past few years as an excellent target for both imaging and therapy of prostate …

Expression of prostate-specific membrane antigen (PSMA) on biopsies is an independent risk stratifier of prostate cancer patients at time of initial diagnosis

MC Hupe, C Philippi, D Roth, C Kümpers… - Frontiers in …, 2018 - frontiersin.org
Background: Stratifying prostate cancer (PCa) patients into risk groups at time of initial
diagnosis enabling a risk-adapted disease management is still a major clinical challenge …

[HTML][HTML] Neuroendocrine differentiation of prostate cancer: a review

V Parimi, R Goyal, K Poropatich… - American journal of …, 2014 - ncbi.nlm.nih.gov
Neuroendocrine cells are one of the epithelial populations in the prostate. Neuroendocrine
differentiation (NED) has been observed in prostate cancer. In addition to small cell …

Using PSMA imaging for prognostication in localized and advanced prostate cancer

MJ Roberts, T Maurer, M Perera, M Eiber… - Nature Reviews …, 2023 - nature.com
The use of prostate-specific membrane antigen (PSMA)-directed applications in modern
prostate cancer management has evolved rapidly over the past few years, helping to …

99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer

SM Hillier, KP Maresca, G Lu, RD Merkin… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and
small-molecule radiopharmaceuticals targeting PSMA rapidly detect the location and extent …

PSMA expression: a potential ally for the pathologist in prostate cancer diagnosis

S Bravaccini, M Puccetti, M Bocchini, S Ravaioli… - Scientific reports, 2018 - nature.com
Prostate cancer (PCa) patients are risk-stratified on the basis of clinical stage and PSA level
at diagnosis and the Gleason Score (GS) in prostate biopsy. However, these parameters are …