On the molecular nature of large-pore channels
J Syrjanen, K Michalski, T Kawate… - Journal of molecular …, 2021 - Elsevier
Membrane transport is a fundamental means to control basic cellular processes such as
apoptosis, inflammation, and neurodegeneration and is mediated by a number of …
apoptosis, inflammation, and neurodegeneration and is mediated by a number of …
Accurate prediction of protein structural flexibility by deep learning integrating intricate atomic structures and Cryo-EM density information
The dynamics of proteins are crucial for understanding their mechanisms. However,
computationally predicting protein dynamic information has proven challenging. Here, we …
computationally predicting protein dynamic information has proven challenging. Here, we …
Pannexin 1 as a driver of inflammation and ischemia–reperfusion injury
Abstract Pannexin 1 (Panx1) is a ubiquitously expressed protein forming large conductance
channels that are central to many distinct inflammation and injury responses. There is …
channels that are central to many distinct inflammation and injury responses. There is …
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids
M Kuzuya, H Hirano, K Hayashida, M Watanabe… - Science …, 2022 - science.org
Pannexin (PANX) family proteins form large-pore channels that mediate purinergic
signaling. We analyzed the cryo-EM structures of human PANX1 in lipid nanodiscs to …
signaling. We analyzed the cryo-EM structures of human PANX1 in lipid nanodiscs to …
ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels
Pannexin 1 (Panx1) is a membrane channel implicated in numerous physiological and
pathophysiological processes via its ability to support release of ATP and other cellular …
pathophysiological processes via its ability to support release of ATP and other cellular …
Cryo-EM structure of human heptameric pannexin 2 channel
H Zhang, S Wang, Z Zhang, M Hou, C Du… - Nature …, 2023 - nature.com
Abstract Pannexin 2 (Panx2) is a large-pore ATP-permeable channel with critical roles in
various physiological processes, such as the inflammatory response, energy production and …
various physiological processes, such as the inflammatory response, energy production and …
Structural and functional analysis of human pannexin 2 channel
Abstract The pannexin 2 channel (PANX2) participates in multiple physiological processes
including skin homeostasis, neuronal development, and ischemia-induced brain injury …
including skin homeostasis, neuronal development, and ischemia-induced brain injury …
Structure versus function: Are new conformations of pannexin 1 yet to be resolved?
Pannexin 1 (Panx1) plays a decisive role in multiple physiological and pathological settings,
including oxygen delivery to tissues, mucociliary clearance in airways, sepsis, neuropathic …
including oxygen delivery to tissues, mucociliary clearance in airways, sepsis, neuropathic …
Pannexin 1 channels as a therapeutic target: Structure, inhibition, and outlook
KE Navis, CY Fan, T Trang, RJ Thompson… - ACS Chemical …, 2020 - ACS Publications
Pannexin 1 (Panx1) channels are transmembrane proteins that release adenosine
triphosphate and play an important role in intercellular communication. They are widely …
triphosphate and play an important role in intercellular communication. They are widely …
Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly
Volume-regulated anion channels (VRACs) mediate volume regulatory Cl-and organic
solute efflux from vertebrate cells. VRACs are heteromeric assemblies of LRRC8A-E …
solute efflux from vertebrate cells. VRACs are heteromeric assemblies of LRRC8A-E …