Circuits and functions of the lateral habenula in health and in disease

H Hu, Y Cui, Y Yang - Nature Reviews Neuroscience, 2020 - nature.com
The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

Neuroanatomical substrates of rodent social behavior: the medial prefrontal cortex and its projection patterns

J Ko - Frontiers in neural circuits, 2017 - frontiersin.org
Social behavior encompasses a number of distinctive and complex constructs that form the
core elements of human imitative culture, mainly represented as either affiliative or …

[HTML][HTML] Understanding the habenula: A major node in circuits regulating emotion and motivation

JL Ables, K Park, I Ibañez–Tallon - Pharmacological research, 2023 - Elsevier
Over the last decade, the understanding of the habenula has rapidly advanced from being
an understudied brain area with the Latin name 'habena” meaning “little rein”, to being …

[HTML][HTML] Cell-type-specific population dynamics of diverse reward computations

EL Sylwestrak, YJ Jo, S Vesuna, X Wang, B Holcomb… - Cell, 2022 - cell.com
Computational analysis of cellular activity has developed largely independently of modern
transcriptomic cell typology, but integrating these approaches may be essential for full …

Disrupted habenula function in major depression

RP Lawson, CL Nord, B Seymour, DL Thomas… - Molecular …, 2017 - nature.com
The habenula is a small, evolutionarily conserved brain structure that plays a central role in
aversive processing and is hypothesised to be hyperactive in depression, contributing to the …

Anatomical and single-cell transcriptional profiling of the murine habenular complex

ML Wallace, KW Huang, D Hochbaum, M Hyun… - Elife, 2020 - elifesciences.org
The lateral habenula (LHb) is an epithalamic brain structure critical for processing and
adapting to negative action outcomes. However, despite the importance of LHb to behavior …

Translating the habenula—from rodents to humans

LJ Boulos, E Darcq, BL Kieffer - Biological psychiatry, 2017 - Elsevier
The habenula (Hb) is a central structure connecting forebrain to midbrain regions. This
microstructure regulates monoaminergic systems, notably dopamine and serotonin, and …

Habenular connections with the dopaminergic and serotonergic system and their role in stress‐related psychiatric disorders

M Metzger, R Souza, LB Lima, D Bueno… - European Journal of …, 2021 - Wiley Online Library
The habenula (Hb) is a phylogenetically old epithalamic structure differentiated into two
nuclear complexes, the medial (MHb) and lateral habenula (LHb). After decades of search …

Excitatory pathways from the lateral habenula enable propofol-induced sedation

C Gelegen, G Miracca, MZ Ran, EC Harding, Z Ye… - Current Biology, 2018 - cell.com
The lateral habenula has been widely studied for its contribution in generating reward-
related behaviors [1, 2]. We have found that this nucleus plays an unexpected role in the …

Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving

DS Zahm, DH Root - Pharmacology Biochemistry and Behavior, 2017 - Elsevier
The cytology and connections of the lateral habenula (LHb) are reviewed. The habenula is
first introduced, after which the cytology of the LHb is discussed mainly with reference to cell …