Clinical and laboratory studies performed over the past few decades have discovered that
dry eye is a chronic inflammatory disease that can be initiated by numerous extrinsic or …

Dry eye is a common ocular surface inflammatory disease that significantly affects quality of
life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular …

The aim of the subcommittee report was to review published evidence describing tear film
changes secondary to contact lens wear and to examine the evidence for associations …

The lacrimal film has attracted increasing interest in the last decades as a potential source of
biomarkers of physiopathological states, due to its accessibility, moderate complexity, and …

Contact lens materials have undergone significant changes over the past 20 years,
particularly with respect to the introduction of silicone hydrogel materials. Whilst this …

Eye‐care practitioners typically associate ocular inflammation during contact lens wear with
serious complications such as microbial keratitis; however, more subtle mechanisms may be …

Purpose To determine if controlled environmental conditions can induce acute
exacerbations of signs and symptoms in dry eye and asymptomatic subjects. Design …

Tear exchange beneath a contact lens facilitates ongoing fluid replenishment between the
ocular surface and the lens. This exchange is considerably lower during the wear of soft …

Perineuronal nets (PNNs) surrounding fast-spiking, parvalbumin (PV) interneurons provide
excitatory: inhibitory balance, which is impaired in several disorders associated with altered …

Immune cells in the exposed conjunctiva mucosa defend against environmental and
microbial stresses. Expression profiling by single-cell RNA sequencing was performed to …