Although carbon is the central element of organic chemistry, oxygen is the central element of
stereoelectronic control in organic chemistry. Generally, a molecule with a C–O bond has …

This Perspective illustrates the defining characteristics of free radical chemistry, beginning
with its rich and storied history. Studies from our laboratory are discussed along with recent …

Hydrogen-atom transfer mediated by earth-abundant transition-metal hydrides (M-Hs) has
emerged as a powerful tool in organic synthesis. Current methods to generate M-Hs most …

Cofactor-mimetic aerobic oxidation has conceptually merged with catalysis of syngas
reactions to form a wide range of Markovnikov-selective olefin radical …

The pool of abundant chiral terpene building blocks (ie,“chiral pool terpenes”) has long
served as a starting point for the chemical synthesis of complex natural products, including …

The rapid generation of molecular complexity from simple starting materials is of paramount
importance in synthetic chemistry. The unique combination of high reactivity and high …

First-row transition-metal-mediated reactions constitute an important and growing area of
research due to the low cost, low toxicity, and exceptional synthetic versatility of these …

We report the discovery of an outstanding reductant for metal-catalyzed radical
hydrofunctionalization reactions. Observations of unexpected silane solvolysis distributions …

Verruculogen and fumitremorgin A are bioactive alkaloids that contain a unique eight-
membered endoperoxide. Although related natural products such as fumitremorgins B and …

Synthetic chemistry plays an indispensable role in drug discovery, contributing to hit
compounds identification, lead compounds optimization, candidate drugs preparation, and …