In chronic infections and in cancer, persistent antigen stimulation under suboptimal
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …

The failure of a massive influx of tumor-infiltrating T lymphocytes to eradicate tumor cells in
the tumor microenvironment is mainly due to the dysfunction of T cells hyporesponsive to …

Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal
hematopoietic stem cell diseases arising from the bone marrow (BM), and approximately …

T cell immunoglobulin and mucin domain 3 (TIM-3) expression on malignant cells has been
reported in some leukemias. In myelodysplastic syndrome (MDS), increased TIM-3 …

Introduction: The promotion of antitumor response by targeting co-stimulatory B7 superfamily
members has become evident to create a new wave of cancer immunotherapy. Inducible Co …

Acute myeloid leukemia (AML) patients rarely have long first remissions (LFRs;> 5 y) after
standard-of-care chemotherapy, unless classified as favorable risk at presentation …

Ovarian cancer is a common gynecological malignancy, and its treatment remains
challenging. Although ovarian cancer may respond to immunotherapy because of …

Introduction: The recent success of checkpoint-inhibitors in cancer treatment paved the way
for the development of new strategies of agonist and antagonist agents against B7 …

We have reported previously that CD33 hi myeloid-derived suppressor cells (MDSCs) play a
direct role in the pathogenesis of myelodysplastic syndromes (MDSs) and that their …

Objective To investigate the association between the T cell inhibitory receptor programmed
death 1 (PD-1) and T cell exhaustion status in T cells from patients with de novo acute …