Adenosine is an endogenous purine-based nucleoside expressed nearly in all body tissues.
It regulates various body functions by activating four G-protein coupled receptors, A 1, A 2A …

Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that
hydrolyse extracellular purine and pyrimidine nucleotides, eg, ATP, UTP, ADP, UDP, AMP …

Agonists of the Gi protein-coupled A3 adenosine receptor (A3AR) have shown important
pain-relieving properties in preclinical settings of several pain models. Active as a …

Adenosine is a signaling molecule, which, by activating its receptors, acts as an important
player after cerebral ischemia. Here, we review data in the literature describing A2BR …

Essential tremor (ET) is one of the most common neurological disorders that often affects
people in the prime of their lives, leading to a significant reduction in their quality of life …

Adenosine receptors (ARs) have been identified as promising therapeutic targets for
countless pathological conditions, spanning from inflammatory diseases to central nervous …

The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is
hampered by the propensity of GPCRs to couple to multiple intracellular signalling …

Ligands of the Gi protein-coupled adenosine A3 receptor (A3R) are receiving increasing
interest as attractive therapeutic tools for the treatment of a number of pathological …

Background Adenosine, acting as a regulator by mediating the activation of G protein-
coupled adenosine receptor families (A1, A2A, A2B, and A3), plays an important role under …

Endometriosis is an estrogen-dependent gynecological disease, with an associated chronic
inflammatory component, characterized by the presence of endometrial tissue outside the …