Abstract Estrogen receptor-positive (ER+) breast cancer accounts for approximately 75% of
all breast cancers. Endocrine therapies, including selective ER modulators (SERMs) …

The estrogen receptor alpha (ERα) is a steroid receptor that is pivotal in the initiation and
progression of most breast cancers. ERα regulates gene transcription through recruitment of …

The molecular events and transcriptional plasticity driving brain metastasis in clinically
relevant breast tumor subtypes has not been determined. Here we comprehensively dissect …

Renal fibrosis is the final common result of a variety of progressive injuries leading to
chronic renal failure. However, there are no effective clinical available drugs for the …

Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is
a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear …

Background SND1 participates in tumorigenesis, tumour invasion and metastasis in different
cancers. Previous studies have shown that SND1 can promote the invasion and migration of …

Simple Summary Breast cancer is one of the most commonly diagnosed malignancies in
women and is also a leading cause of cancer related death. Estrogens play crucial roles in …

The human cell requires ways to specify its transcriptome without altering the essential
sequence of DNA; this is achieved through mechanisms which govern the epigenetic state …

The breast epithelium, vital for mammary gland function, is influenced by oestrogen through
the oestrogen receptor (ER) signalling pathway. Luminal breast cancer (BC), characterised …

Objectives Killer cell lectin like receptor G1 (KLRG1) is identified as a co-inhibitory receptor
for NK cells and antigen-experienced T cells. The role of KLRG1 in immune regulation in …