Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Background The abundance of energy metabolites is intimately interconnected with the
activity of chromatin-modifying enzymes in order to guarantee the finely tuned modulation of …

Aims/hypothesis Nicotinamide-N-methyltransferase (NNMT) was recently shown to be
upregulated in mouse models of insulin resistance and obesity. So far, it is unknown …

Melanoma accounts for less than 5% of all cutaneous neoplasms but is responsible for the
greater part of skin cancer–related deaths. Therefore, the identification of molecules that …

Methods: We searched public databases including PubMed, MEDLINE Springer, Elsevier
Science Direct, Cochrane Library and Google Scholar before December 2012. To collect …

Gastrointestinal (GI) neoplasms include esophageal, gastric, colorectal, hepatic, and
pancreatic cancers. They are characterized by asymptomatic behavior, being responsible for …

The head and neck tumors (HNT) are a heterogeneous group of diseases ranging from
benign to malignant lesions, with distinctive molecular and clinical behaviors. Several …

Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation reaction of
nicotinamide, using S-adenosyl-L-methionine as the methyl donor. Enzyme overexpression …

Purpose: To identify potential molecular hubs that regulate oncogenic kinases and target
them to improve treatment outcomes for glioblastoma patients. Experimental Design: Data …

Abstract Background/Aims: Head and neck squamous cell carcinoma (HNSCC) ranks sixth
worldwide for tumor-related mortality. A subpopulation of tumor cells, termed cancer stem …