Pathophysiology of systemic sclerosis: current understanding and new insights
ABSTRACT Introduction: Systemic sclerosis (SSc) is a complex autoimmune connective
tissue disease characterized by chronic and progressive tissue and organ fibrosis with …
tissue disease characterized by chronic and progressive tissue and organ fibrosis with …
Integrating mechanisms of pulmonary fibrosis
TA Wynn - Journal of Experimental Medicine, 2011 - rupress.org
Pulmonary fibrosis is a highly heterogeneous and lethal pathological process with limited
therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has …
therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has …
Nintedanib for systemic sclerosis–associated interstitial lung disease
O Distler, KB Highland, M Gahlemann… - … England Journal of …, 2019 - Mass Medical Soc
Background Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis
and a leading cause of systemic sclerosis–related death. Nintedanib, a tyrosine kinase …
and a leading cause of systemic sclerosis–related death. Nintedanib, a tyrosine kinase …
Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease
E Valenzi, M Bulik, T Tabib, C Morse… - Annals of the …, 2019 - ard.bmj.com
Objectives Myofibroblasts are key effector cells in the extracellular matrix remodelling of
systemic sclerosis-associated interstitial lung disease (SSc-ILD); however, the diversity of …
systemic sclerosis-associated interstitial lung disease (SSc-ILD); however, the diversity of …
A circulating cell population showing both M1 and M2 monocyte/macrophage surface markers characterizes systemic sclerosis patients with lung involvement
Abstract Background Systemic sclerosis (SSc) is a disorder characterized by immune system
alterations, vasculopathy and fibrosis. SSc-related interstitial lung disease (ILD) represents a …
alterations, vasculopathy and fibrosis. SSc-related interstitial lung disease (ILD) represents a …
The immunopathogenesis of fibrosis in systemic sclerosis
M Brown, S O'Reilly - Clinical & Experimental Immunology, 2019 - academic.oup.com
Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized
by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction …
by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction …
[HTML][HTML] Cytokine mediated tissue fibrosis
Acute inflammation is a recognised part of normal wound healing. However, when
inflammation fails to resolve and a chronic inflammatory response is established this …
inflammation fails to resolve and a chronic inflammatory response is established this …
Cellular interactions in the pathogenesis of interstitial lung diseases
G Bagnato, S Harari - European Respiratory Review, 2015 - Eur Respiratory Soc
Interstitial lung disease (ILD) encompasses a large and diverse group of pathological
conditions that share similar clinical, radiological and pathological manifestations, despite …
conditions that share similar clinical, radiological and pathological manifestations, despite …
Genetics and genomics of pulmonary arterial hypertension
Major discoveries have been obtained within the last decade in the field of hereditary
predisposition to pulmonary arterial hypertension (PAH). Among them, the identification of …
predisposition to pulmonary arterial hypertension (PAH). Among them, the identification of …
The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin
CT Weaver, CO Elson, LA Fouser… - Annual Review of …, 2013 - annualreviews.org
The recent discovery of a new CD4+ T cell subset, Th17, has transformed our understanding
of the pathogenetic basis of an increasing number of chronic immune-mediated diseases …
of the pathogenetic basis of an increasing number of chronic immune-mediated diseases …