Understanding the role of gut microbiome–host metabolic signal disruption in health and disease

E Holmes, JV Li, T Athanasiou, H Ashrafian… - Trends in …, 2011 - cell.com
There is growing awareness of the importance of the gut microbiome in health and disease,
and recognition that the microbe to host metabolic signalling is crucial to understanding the …

AHNAK: the giant jack of all trades

TA Davis, B Loos, AM Engelbrecht - Cellular signalling, 2014 - Elsevier
The nucleoprotein AHNAK is an unusual and somewhat mysterious scaffolding protein
characterised by its large size of approximately 700 kDa. Several aspects of this protein …

Gut microbiome response to sucralose and its potential role in inducing liver inflammation in mice

X Bian, L Chi, B Gao, P Tu, H Ru, K Lu - Frontiers in physiology, 2017 - frontiersin.org
Sucralose is the most widely used artificial sweetener, and its health effects have been
highly debated over the years. In particular, previous studies have shown that sucralose …

Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction …

SHT Lee, KM Garske, UT Arasu, A Kar, Z Miao… - …, 2024 - thelancet.com
Background Abdominal obesity increases the risk for non-alcoholic fatty liver disease
(NAFLD), now known as metabolic dysfunction-associated steatotic liver disease (MASLD) …

A 1H NMR-Based Metabonomic Investigation of Time-Related Metabolic Trajectories of the Plasma, Urine and Liver Extracts of Hyperlipidemic Hamsters

C Jiang, K Yang, L Yang, Z Miao, Y Wang, H Zhu - PloS one, 2013 - journals.plos.org
The hamster has been previously found to be a suitable model to study the changes
associated with diet-induced hyperlipidemia in humans. Traditionally, studies of …

New Nordic diet versus average Danish diet: a randomized controlled trial revealed healthy long-term effects of the new Nordic diet by GC–MS blood plasma …

B Khakimov, SK Poulsen, F Savorani… - Journal of proteome …, 2016 - ACS Publications
A previous study has shown effects of the New Nordic Diet (NND) to stimulate weight loss
and lower systolic and diastolic blood pressure in obese Danish women and men in a …

A preliminary study on postmortem interval estimation of suffocated rats by GC-MS/MS-based plasma metabolic profiling

T Sato, K Zaitsu, K Tsuboi, M Nomura… - Analytical and …, 2015 - Springer
Estimation of postmortem interval (PMI) is an important goal in judicial autopsy. Although
many approaches can estimate PMI through physical findings and biochemical tests …

1H NMR-based metabolomics approach reveals metabolic alterations in response to dietary imbalances in Megalobrama amblycephala

P Prathomya, W Prisingkorn, I Jakovlić, FY Deng… - Metabolomics, 2017 - Springer
Introduction High-fat and high-carbohydrate diets cause a number of metabolic disorders in
mammals. However, little is known about metabolomic changes caused by dietary …

Chronic caloric restriction partially protects against age-related alteration in serum metabolome

JM De Guzman, G Ku, R Fahey, YH Youm, I Kass… - Age, 2013 - Springer
Calorie restriction (CR) remains the most robust metabolic intervention to extend lifespan
and improve healthspan in several species. Using global and targeted mass spectrometry …

[HTML][HTML] Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells

JM Suh, Y Son, JY Yoo, Y Goh, NG Seidah, S Lee… - Neoplasia, 2021 - Elsevier
Previously we demonstrated that Ahnak mediates transforming growth factor-β (TGFβ)-
induced epithelial-mesenchymal transition (EMT) during tumor metastasis. It is well-known …