Endophenotypes, measurable components unseen by the unaided eye along the pathway
between disease and distal genotype, have emerged as an important concept in the study of …

The contributions of the Rochester (Minnesota) Epidemiology Project and Mayo Clinic
studies in the evaluation of the causes of epilepsy are summarized. The development of the …

Epilepsy affects at least 2% of the population at some time in their lives1. The epilepsies are
a heterogeneous group of disorders, many with an inherited component2. Although specific …

Although many genes that predispose for epilepsy in humans have been determined, those
that underlie the classical syndromes of idiopathic generalized epilepsy (IGE) have yet to be …

We made a long term prospective study of 66 patients with juvenile myoclonic epilepsy
(JME). Prevalence was 10.2% among 672 patients with epilepsies. Sex distribution was …

We studied twins to examine the genetics of epilepsy syndromes. We ascertained 358 twin
pairs in whom one or both reported seizures. After evaluation, 253 of 358 (71%) had seizure …

Progressive myoclonus epilepsy of the Unverricht-Lundborg type (EPM1) is an autosomal
recessive inherited form of epilepsy, previously linked to human chromosome 21q22. 3. The …

Failure to obtain convincing results in psychiatric genetics can partly be attributed to the fact
that progress in molecular biology and genetic epidemiology has not been followed by an …

There is strong evidence for a genetic contribution to epilepsy, but it is commonly assumed
that this genetic contribution is limited to 'generalized'epilepsies, and that most forms of …

Phenotypic variability and likely extensive genetic heterogeneity have been confounding the
search for the causes of schizophrenia since the inception of the diagnostic category. The …