Celiac disease (CD) is an intestinal disorder with multifactorial etiology. HLA and non-HLA
genes together with gluten and possibly additional environmental factors are involved in …

Rapid advances in molecular biological techniques have made it possible to study disease
pathogenesis at a genomic level. T cell receptor (TCR) gene rearrangement is an important …

Celiac disease, also known as celiac sprue, is a gluten-induced autoimmune-like disorder of
the small intestine, which is strongly associated with HLA-DQ2. The structure of DQ2 …

The development of epitope-based vaccines, which have wide population coverage, is
greatly complicated by MHC polymorphism. The grouping of alleles into supertypes, on the …

Highlights•The MHC is the most important genetic risk factor in common autoimmune
diseases.•For one disease there can be independent contributions by several distinct MHC …

In this study, a large number of naturally processed peptides was isolated and identified
from the human diabetes-susceptible class II MHC molecules HLA-DQ8 (DQA1* 0301 …

Type 1 diabetes is a T cell mediated autoimmune disease, characterised by the selective
destruction of pancreatic β cells, and susceptibility is determined by a combination of genetic …

Celiac disease (CD) is an autoimmune disorder induced by gluten intake in genetically
susceptible individuals. It is characterized by the presence of serum antibodies to …

Early studies of genetic susceptibility to pemphigus vulgaris (PV) showed associations
between human leukocyte antigen (HLA) DR4 and DR6 and disease. The emergence of …

Abstract Knowledge of the binding repertoires and specificities of HLA-DQ molecules is
somewhat limited and contradictory, partly because of the scarcity of reports addressing …