Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions

I Klaassen, CJF Van Noorden… - Progress in retinal and …, 2013 - Elsevier
Breakdown of the inner endothelial blood-retinal barrier (BRB), as occurs in diabetic
retinopathy, age-related macular degeneration, retinal vein occlusions, uveitis and other …

More than just water channels: unexpected cellular roles of aquaporins

AS Verkman - Journal of cell science, 2005 - journals.biologists.com
Aquaporins (AQPs) are membrane proteins that transport water and, in some cases, also
small solutes such as glycerol. AQPs are expressed in many fluid-transporting tissues, such …

Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption

S Saadoun, MC Papadopoulos, M Hara-Chikuma… - Nature, 2005 - nature.com
Abstract Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular
endothelia, where it increases cell membrane water permeability,,. The role of AQP1 in …

Aquaporins in cancer biology

CS Moon, D Moon, SK Kang - Frontiers in oncology, 2022 - frontiersin.org
Aquaporins (AQPs) are a family of transmembrane water channel proteins, which were
initially characterized as a novel protein family that plays a vital role in transcellular and …

Role of human aquaporin 5 in colorectal carcinogenesis

SK Kang, YK Chae, J Woo, MS Kim, JC Park… - The American journal of …, 2008 - Elsevier
While overexpression of several aquaporins (AQPs) has been reported in different types of
human cancer, the role of AQPs in carcinogenesis has not been clearly defined. Here, by …

Aquaporin-1 facilitates epithelial cell migration in kidney proximal tubule

M Hara-Chikuma, AS Verkman - Journal of the American Society …, 2006 - journals.lww.com
Abstract Aquaporin-1 (AQP1) is the principal water-transporting protein in cell plasma
membranes in kidney proximal tubule, where it facilitates transepithelial water transport …

Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth

MO Hoque, JC Soria, J Woo, T Lee, J Lee… - The American journal of …, 2006 - Elsevier
The aquaporins represent a family of transmembrane water channel proteins that play a
major role in trans-cellular and transepithelial water movement. Most tumors have been …

Mechanisms of aquaporin-facilitated cancer invasion and metastasis

ML De Ieso, AJ Yool - Frontiers in chemistry, 2018 - frontiersin.org
Cancer is a leading cause of death worldwide, and its incidence is rising with numbers
expected to increase 70% in the next two decades. The fact that current mainline treatments …

Expression of aquaporin 5 increases proliferation and metastasis potential of lung cancer

Z Zhang, Z Chen, Y Song, P Zhang… - The Journal of …, 2010 - Wiley Online Library
Abstract Water channel aquaporin 5 (AQP5) is highly expressed at the apical membrane of
alveolar type I epithelial cells and confers high osmotic water permeability. AQP5 is also …

Endothelial cells in the bone marrow of patients with multiple myeloma

A Vacca, R Ria, F Semeraro, F Merchionne, M Coluccia… - Blood, 2003 - ashpublications.org
Endothelial cells (EC) were extracted through a lectin-based method from bone marrow of
57 patients with active multiple myeloma (MM) and compared with their healthy quiescent …