Modern cancer therapy has successfully cured many cancers and converted a terminal
illness into a chronic disease. Because cancer patients often have coexisting heart …

Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and
contractile dysfunction. Genetic mutations involving genes that encode cytoskeletal …

Survivors of childhood, adolescent, and young adult cancer, previously treated with
anthracycline chemotherapy (including mitoxantrone) or radiotherapy in which the heart was …

Survivors of childhood cancer treated with anthracycline chemotherapy or chest radiation
are at an increased risk of developing congestive heart failure. In this population, congestive …

1928 Circulation October 22, 2013 mental health, functional status, activity limitations,
cancerrelated pain, and cancer-related anxiety) declined moderately to severely in 44%. 5 …

Importance Anthracyclines are part of many effective pediatric cancer treatment protocols.
Most pediatric oncology treatment groups assume that the hematologic toxicity of …

Background: Treatment-related cardiac death is the primary, noncancer cause of mortality in
adult survivors of childhood malignancies. Early detection of cardiac dysfunction may …

Anthracyclines are used in over 50% of childhood cancer treatment protocols, but their
clinical usefulness is limited by anthracycline-induced cardiotoxicity (ACT) manifesting as …

The management of individual patients requiring anthracyclines remains challenging
because uncertainty persists on predictors of cardiotoxicity. We aimed to perform a …

Purpose To create clinically useful models that incorporate readily available demographic
and cancer treatment characteristics to predict individual risk of heart failure among 5-year …