Placental origins of chronic disease
Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …
events during their intrauterine phase of development. Biologically this should not be …
High-altitude adaptation: mechanistic insights from integrated genomics and physiology
JF Storz - Molecular biology and evolution, 2021 - academic.oup.com
Population genomic analyses of high-altitude humans and other vertebrates have identified
numerous candidate genes for hypoxia adaptation, and the physiological pathways …
numerous candidate genes for hypoxia adaptation, and the physiological pathways …
Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data
High-altitude hypoxia (reduced inspired oxygen tension due to decreased barometric
pressure) exerts severe physiological stress on the human body. Two high-altitude regions …
pressure) exerts severe physiological stress on the human body. Two high-altitude regions …
Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: a database for parameters required in physiologically based …
K Abduljalil, P Furness, TN Johnson… - Clinical …, 2012 - Springer
Background: Pregnancy is associated with considerable changes in the physiological,
anatomical and biochemical attributes in women. These may alter the exposure to …
anatomical and biochemical attributes in women. These may alter the exposure to …
Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates
High-altitude environments provide ideal testing grounds for investigations of mechanism
and process in physiological adaptation. In vertebrates, much of our understanding of the …
and process in physiological adaptation. In vertebrates, much of our understanding of the …
Measuring high-altitude adaptation
LG Moore - Journal of applied physiology, 2017 - journals.physiology.org
High altitudes (> 8,000 ft or 2,500 m) provide an experiment of nature for measuring
adaptation and the physiological processes involved. Studies conducted over the past~ 25 …
adaptation and the physiological processes involved. Studies conducted over the past~ 25 …
Gestational hypoxia and developmental plasticity
Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …
Human genetic adaptation to high altitude: evidence from the Andes
Whether Andean populations are genetically adapted to high altitudes has long been of
interest. Initial studies focused on physiological changes in the O2 transport system that …
interest. Initial studies focused on physiological changes in the O2 transport system that …
Placental nutrient transport and intrauterine growth restriction
F Gaccioli, S Lager - Frontiers in physiology, 2016 - frontiersin.org
Intrauterine growth restriction refers to the inability of the fetus to reach its genetically
determined potential size. Fetal growth restriction affects approximately 5–15% of all …
determined potential size. Fetal growth restriction affects approximately 5–15% of all …
Humans at high altitude: hypoxia and fetal growth
High-altitude studies offer insight into the evolutionary processes and physiological
mechanisms affecting the early phases of the human lifespan. Chronic hypoxia slows fetal …
mechanisms affecting the early phases of the human lifespan. Chronic hypoxia slows fetal …