Genetics of rheumatoid arthritis susceptibility, severity, and treatment response

S Viatte, A Barton - Seminars in immunopathology, 2017 - Springer
A decade after the first genome-wide association study in rheumatoid arthritis (RA), a
plethora of genetic association studies have been published on RA and its clinical or …

Systematic review and meta-analysis: pharmacogenetics of anti-TNF treatment response in rheumatoid arthritis

S Bek, AB Bojesen, JV Nielsen, J Sode… - The …, 2017 - nature.com
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects~ 1% of the
Caucasian population. Over the last decades, the availability of biological drugs targeting …

[图书][B] Firestein & Kelley's Textbook of Rheumatology-E-Book

GS Firestein, IB McInnes, G Koretzky, T Mikuls, T Neogi… - 2024 - books.google.com
With its comprehensive, global coverage of all aspects of diagnosis, screening, and
treatment in both adults and children, Firestein & Kelley's Textbook of Rheumatology …

Multi-omics approach to precision medicine for immune-mediated diseases

M Ota, K Fujio - Inflammation and regeneration, 2021 - Springer
Recent innovation in high-throughput sequencing technologies has drastically empowered
the scientific research. Consequently, now, it is possible to capture comprehensive profiles …

Biomarkers to predict DMARDs efficacy and adverse effect in rheumatoid arthritis

K Wei, P Jiang, J Zhao, Y Jin, R Zhang… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA), one of the most common immune system diseases, mainly affects
middle-aged and elderly individuals and has a serious impact on the quality of life of …

Genetic and epigenetic predictors of responsiveness to treatment in RA

D Plant, AG Wilson, A Barton - Nature Reviews Rheumatology, 2014 - nature.com
Methotrexate and TNF-blocking agents are the DMARDs most commonly prescribed for the
treatment of rheumatoid arthritis (RA). However, not all patients treated with these …

[PDF][PDF] Differential methylation as a biomarker of response to etanercept in patients with rheumatoid arthritis

D Plant, A Webster, N Nair, J Oliver… - Arthritis & …, 2016 - Wiley Online Library
Objective Biologic drug therapies represent a huge advance in the treatment of rheumatoid
arthritis (RA). However, very good disease control is achieved in only 30% of patients …

Right drug, right patient, right time: aspiration or future promise for biologics in rheumatoid arthritis?

VC Romão, EM Vital, JE Fonseca, MH Buch - Arthritis research & therapy, 2017 - Springer
Individualising biologic disease-modifying anti-rheumatic drugs (bDMARDs) to maximise
outcomes and deliver safe and cost-effective care is a key goal in the management of …

Potential clinical biomarkers in rheumatoid arthritis with an omic approach

Y Puentes-Osorio, P Amariles, MÁ Calleja… - Autoimmunity …, 2021 - Springer
Objective To aid in the selection of the most suitable therapeutic option in patients with
diagnosis of rheumatoid arthritis according to the phase of disease, through the review of …

Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis

J Massey, D Plant, K Hyrich, AW Morgan… - The …, 2018 - nature.com
Rheumatoid arthritis (RA) is characterised by chronic synovial joint inflammation. Treatment
has been revolutionised by tumour necrosis factor alpha inhibitors (TNFi) but each available …