The long and short non-coding RNAs modulating EZH2 signaling in cancer

S Mirzaei, MH Gholami, K Hushmandi… - Journal of hematology & …, 2022 - Springer
Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in
encoding proteins. However, they participate in developmental and biological processes …

TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis

Y Hao, D Baker, P Ten Dijke - International journal of molecular sciences, 2019 - mdpi.com
Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation,
migration, and the differentiation of a plethora of different cell types. Consistent with these …

Long noncoding RNA s as regulators of cancer immunity

N Denaro, MC Merlano, C Lo Nigro - Molecular oncology, 2019 - Wiley Online Library
Long noncoding RNA s (lnc RNA s) are increasingly known to be important in cancer as they
directly interact with the cell cycle, proliferation pathways and microbiome balance …

Long non-coding RNAs as the critical regulators of PI3K/AKT, TGF-β, and MAPK signaling pathways during breast tumor progression

A Maharati, M Moghbeli - Journal of translational medicine, 2023 - Springer
Breast cancer (BC) as one of the most common causes of human deaths among women, is
always considered one of the global health challenges. Despite various advances in …

DNMT1-mediated epigenetic silencing of TRAF6 promotes prostate cancer tumorigenesis and metastasis by enhancing EZH2 stability

Z Li, B Li, H Yu, P Wang, W Wang, P Hou, M Li, S Chu… - Oncogene, 2022 - nature.com
A plethora of studies have shown that both DNMT1 and EZH2 have great effects on the
progression of a variety of cancers. However, it remains unclear whether the expression …

Long non-coding RNA/epithelial-mesenchymal transition axis in human cancers: Tumorigenesis, chemoresistance, and radioresistance

M Hashemi, S Hajimazdarany, CD Mohan… - Pharmacological …, 2022 - Elsevier
Epithelial-to-mesenchymal transition (EMT) is a process that involves the transformation of
polarized epithelial cells to attain a mesenchymal phenotype that presents an elevated …

Long noncoding RNA SNHG15 promotes human breast cancer proliferation, migration and invasion by sponging miR-211-3p

Q Kong, M Qiu - Biochemical and biophysical research communications, 2018 - Elsevier
Long non-coding RNAs (lncRNA) have been demonstrated to act as essential regulators in
the development and progression of breast cancer. In our study, we found that long …

Super-enhancer–associated long noncoding RNA HCCL5 is activated by ZEB1 and promotes the malignancy of hepatocellular carcinoma

L Peng, B Jiang, X Yuan, Y Qiu, J Peng, Y Huang… - Cancer research, 2019 - AACR
Hepatocellular carcinoma (HCC) is one of the most dominant causes of neoplasm-related
deaths worldwide. In this study, we identify and characterize HCCL5, a novel cytoplasmic …

PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression

Z Li, C Chen, H Yong, L Jiang, P Wang, S Meng… - Cell death & …, 2023 - nature.com
Abstract Protein arginine methyltransferase 2 (PRMT2) is involved in several biological
processes via histone methylation and transcriptional regulation. Although PRMT2 has been …

The roles of long noncoding RNAs in breast cancer metastasis

L Liu, Y Zhang, J Lu - Cell death & disease, 2020 - nature.com
Breast cancer is the most significant threat to female health. Breast cancer metastasis is the
major cause of mortality in breast cancer patients. To fully unravel the molecular …