Protein hydration dynamics plays an important role in many physiological processes since
protein fluctuations, slow solvation, and the dynamics of hydrating water are all intrinsically …

To understand complex molecular interactions, it is necessary to account for molecular
flexibility and the available equilibrium of conformational states. Only a small number of …

Spectrin is a multifunctional, multi-domain protein most well known in the membrane
skeleton of mature human erythrocytes. Here we review the literature on the crosstalk of the …

Among the major challenges in the development of biopharmaceuticals are structural
heterogeneity and aggregation. The development of a successful therapeutic monoclonal …

Red edge excitation shift (REES) spectroscopy relies on the unique emission profiles of
fluorophore–solvent interactions to profile protein molecular dynamics. Recently, we …

Spectrin, a major component of the eukaryotic membrane skeleton, has been shown to have
chaperone like activity. Here we investigate the pH induced changes in the structure and …

Protein isoforms are structural variants with changes in the overall flexibility predominantly at
the tertiary level. For membrane associated proteins, such structural flexibility or rigidity …

A novel aminoquinoline derivative (AQ) was synthesized and applied as a solvatochromic
fluorescent probe to study proteins and their alterations. AQ is not fluorescent in aqueous …

G protein-coupled receptors (GPCRs) are major signaling proteins in eukaryotic cells and
are important drug targets. In spite of their role in GPCR function, the extramembranous …

Spectrin is a cytoskeletal protein ubiquitous in metazoan cells that acts as a liaison between
the plasma membrane and the cellular interior and imparts mechanical stability to the …