Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved
in the regulation of fundamental cellular processes, including transcription, RNA processing …

R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

During transcription, the nascent RNA strand can base pair with its template DNA, displacing
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …

DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …

ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian
SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF …

G quadruplexes (G4s) and R loops are noncanonical DNA structures that can regulate basic
nuclear processes and trigger DNA damage, genome instability, and cell killing. By different …

End resection in homologous recombination (HR) and HR-mediated repair of DNA double-
strand breaks (DSBs) removes several kilobases from 5′ strands of DSBs, but 3′ strands …

Much of the mammalian genome is transcribed, generating long non-coding RNAs
(lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the …

Transcription poses a threat to genomic stability through the formation of R-loops that can
obstruct progression of replication forks. R-loops are three-stranded nucleic acid structures …

Genome replication involves dealing with obstacles that can result from DNA damage but
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …