Background The treatment of systemic sclerosis (SSc) represents a great clinical challenge
because of the complex disease pathogenesis including vascular, fibrotic, and immune T …

Calcinosis cutis is the deposition of calcium in the skin and subcutaneous tissues. It affects
almost one quarter of patients with SSc, and is associated with longer disease duration …

Calcinosis cutis is the deposition of insoluble calcium in the skin and subcutaneous tissues.
It represents a major clinical problem in patients with SSc affecting at least one quarter of …

Calcinosis (hydroxyapatite and calcium phosphate crystal deposition) within the
extracellular matrix of the dermis and subcutaneous tissue is a frequent manifestation of …

Systemic sclerosis is an uncommon autoimmune connective tissue disease with multiorgan
system involvement and significant associated morbidity and mortality. Cutaneous signs and …

Calcinosis is one of the hallmark sequelae of juvenile dermatomyositis (JDM), and despite
recent progress in the therapy of JDM, dystrophic calcification still occurs in approximately …

Calcinosis represents a severe complication of several autoimmune disorders. Soft-tissue
calcifications have been classified into five major types: dystrophic, metastatic, idiopathic …

Biologic therapies targeting B-cells are emerging as an effective strategy to treat a variety of
immune-mediated diseases. One of the most studied B-cell-targeted therapies is rituximab …

(1) Background: Calcinosis of the skin mainly appears in connective tissue disorders
(dystrophic subtype). It may cause inflammation, ulceration, pain, and restricted joint …

Introduction Calcinosis is common in patients with systemic sclerosis (SSc) and refers to the
sub-epidermal deposition of calcium salts in the skin. SSc-related calcinosis is associated …