Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally
related proteins that transduces signals from members of TNFR superfamily and various …

Inflammatory bowel diseases (IBDs) are chronic problems of gastrointestinal tract (GIT) with
poorly understood aetiology. Patients with any of the two common entities, Crohn's disease …

Background Accumulating evidence has demonstrated that aberrant expression of
deubiquitinating enzymes is associated with the initiation and progression of Triple-negative …

A significant proportion of the global burden of disease can be attributed to mental illness.
Despite important advances in identifying risk factors for mental health conditions, the …

Background and Purpose: Neuroinflammation has been proven to play an important role in
the pathogenesis of early brain injury after subarachnoid hemorrhage (SAH). EZH2 …

Circular RNAs (circRNAs) are involved in many physiological functions. Whether circulating
circRNAs serve as markers for coronary artery disease (CAD) is unknown. Seven CAD …

Deubiquitinating enzymes (DUBs) regulate numerous cellular functions by removing
ubiquitin modifications. We examined the effects of 88 human DUBs on linear ubiquitin …

p62 is a versatile protein involved in the delicate balance between cell death and survival,
which is fundamental for cell fate decision in the context of both cancer and …

Post-translational modification of cellular proteins by ubiquitin regulates numerous cellular
processes, including cell division, immune responses, and apoptosis. Ubiquitin-mediated …

Failure to clear damaged mitochondria via mitophagy disrupts physiological function and
may initiate damage signaling via inflammatory cascades, although how these pathways …