International consensus statement on allergy and rhinology: rhinosinusitis 2021

RR Orlandi, TT Kingdom, TL Smith… - International forum of …, 2021 - Wiley Online Library
I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

International consensus statement on allergy and rhinology: Allergic rhinitis–2023

SK Wise, C Damask, LT Roland, C Ebert… - International forum of …, 2023 - Wiley Online Library
Background In the 5 years that have passed since the publication of the 2018 International
Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis …

Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial

JK Han, C Bachert, W Fokkens… - The Lancet …, 2021 - thelancet.com
Background Chronic rhinosinusitis with nasal polyps affects approximately 2–4% of the
general population, and long-term use of systemic corticosteroids is associated with adverse …

Efficacy and safety of benralizumab in chronic rhinosinusitis with nasal polyps: a randomized, placebo-controlled trial

C Bachert, JK Han, MY Desrosiers, P Gevaert… - Journal of Allergy and …, 2022 - Elsevier
Background Eosinophilic inflammation has been implicated in the pathogenesis, severity,
and treatment responsiveness of chronic rhinosinusitis with nasal polyps (CRSwNP) …

EUFOREA expert board meeting on uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) and biologics: definitions and management

C Bachert, JK Han, M Wagenmann… - Journal of Allergy and …, 2021 - Elsevier
Uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) is the most
bothersome phenotype of chronic rhinosinusitis; it is typically characterized by a type 2 …

[HTML][HTML] Chronic rhinosinusitis with nasal polyps and asthma

TM Laidlaw, J Mullol, KM Woessner, N Amin… - The Journal of Allergy …, 2021 - Elsevier
Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) characterized by a type 2
immune signature often have severe and recurrent disease. Lower airway conditions such …

[HTML][HTML] Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: a systematic review and …

P Oykhman, FA Paramo, J Bousquet… - Journal of Allergy and …, 2022 - Elsevier
Background Chronic rhinosinusitis with nasal polyposis (CRSwNP) is an inflammatory
condition of the upper airways. Optimal management is unclear. Objective We compared the …

[HTML][HTML] Type 2 inflammation in asthma and other airway diseases

J Maspero, Y Adir, M Al-Ahmad… - ERJ Open …, 2022 - Eur Respiratory Soc
Chronic inflammatory airway diseases, including asthma, chronic rhinosinusitis, eosinophilic
COPD and allergic rhinitis are a global health concern. Despite the coexistence of these …

Endotypes of chronic rhinosinusitis: relationships to disease phenotypes, pathogenesis, clinical findings, and treatment approaches

A Kato, AT Peters, WW Stevens, RP Schleimer… - Allergy, 2022 - Wiley Online Library
Chronic rhinosinusitis (CRS) is a common clinical syndrome that produces significant
morbidity and costs to our health system. The study of CRS has progressed from an era …

[PDF][PDF] EPOS/EUFOREA update on indication and evaluation of Biologics in Chronic Rhinosinusitis with Nasal Polyps 2023

WJ Fokkens, AS Viskens, V Backer, D Conti… - Rhinology, 2023 - sioechcf.it
Severe chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating disease with a
significant impact on the quality of life (QoL). It is typically characterized by a type 2 …