P-glycoprotein (P-gp) is a major factor in the multidrug resistance phenotype in cancer cells.
P-gp is a protein that regulates the ATP-dependent efflux of a wide range of anticancer …

Chemoresistance to platinum‑based chemotherapy for ovarian cancer in the advanced
stage remains a formidable concern clinically. Increasing evidence has revealed that …

Background Dysregulation of both mitochondrial biogenesis and mitophagy is critical to
sustain oncogenic signaling pathways. However, the mechanism of mitophagy in promoting …

Cadmium (Cd), a ubiquitous environmental contaminant, is deemed a possible aetiological
cause of cognitive disorders in humans. Nevertheless, the exact mechanism by which …

The lethality and chemotherapy resistance of pancreatic cancer necessitates the urgent
development of innovative strategies to improve patient outcomes. To address this issue, we …

Breast cancer is the most frequent cancer in women; however, it is curable in most cases (up
to 80%) when detected and treated at an early non-metastatic stage. Nanotechnology has …

TIMM13 (translocase of inner mitochondrial membrane 13) located at the mitochondrial
intermembrane space is vital for the integrity and function of mitochondria. We found that the …

Mitochondrial dysfunction causes the production of reactive oxygen species (ROS) and
oxidative damage, and oxidative stress and inflammation are considered key factors causing …

Abstract A new ligand 2-(1E, 3E, 5E, 7E)-2, 6-dimethyl-8-(2, 6, 6-trimethylcyclohex-1-yl) octa-
1, 2, 5, 7-tetraen-1-yl)-1H-imidazo [4, 5-f][1, 10] phenanthroline (DTOIP) was synthesized …

In the modern cosmetic industry, there has been growing interest in developing plant-
derived products for protecting human skin against ultraviolet (UV) radiation. This study was …