Degraders have illustrated that compound‐induced proximity to E3 ubiquitin ligases can
prompt the ubiquitination and degradation of disease‐relevant proteins. Hence, this …

Adhesion G-protein-coupled receptors (aGPCRs)—a major family of GPCRs—play critical
roles in the regulation of tissue development and cancer progression. The orphan receptor …

Recent studies suggest that immunological and inflammatory responses in cardiovascular
disorders, such as hypertension, myocardial infarction, ischemia injury, heart failure …

In an effort to provide an overview of the biophysical approaches used to study G-protein-
coupled receptors, we chose to consider the adenosine A2A receptor as a model, as it is …

As a key regulator for the renin-angiotensin system, a class AG protein-coupled receptor
(GPCR), AngII type 2 receptor (AT 2 R), plays a pivotal role in the homeostasis of the …

G protein-coupled receptors (GPCRs) are known to dimerize, but the molecular and
structural basis of GPCR dimers is not well understood. In this study, we developed a …

The quantitative FRET analysis of living cells is a tedious and time‐consuming task for
freshman lacks technical training. In this study, FRET imaging and batch processing method …

G-protein-coupled receptors (GPCRs), the largest family of human membrane proteins, play
a crucial role in cellular control and are the target of approximately one-third of all drugs on …

Biologics, which encompass peptides, proteins, nucleotides, and cell-based products are
widely used in both therapeutics and diagnostic applications. Compared to small molecule …

Os recetores acoplados à proteína G (GPCRs) desempenham funções críticas no
desenvolvimento e progressão de diversas patologias. Muitos membros da família GPCR …