This review describes the historical emergence of the concept of bone marrow
mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic …

Cultured mesenchymal stromal cell (MSC) populations are best characterized by the
capacity of some cells within this population to differentiate into mesodermal derivatives …

Differentiation is a key cellular process in normal tissue development that is significantly
altered in cancer. Although molecular signatures characterising pluripotency and …

We introduce a novel dynamic model of stem cell and tissue organisation in murine
intestinal crypts. Integrating the molecular, cellular and tissue level of description, this model …

Mesenchymal stem cells (MSCs) are under intensive investigation for use in cell-based
therapies because their differentiation abilities, immunomodulatory effects, and homing …

Inconsistencies among in vitro and in vivo experiments using adult mesenchymal stem cells
(MSCs) confound development of therapeutic, regenerative medicine applications, and in …

In recent years, the mathematical and computational sciences have developed novel
methodologies and insights that can aid in designing advanced bioreactors, microfluidic …

In the bone marrow of vertebrates, two types of stem cells coexist—hematopoietic stem cells
(HSCs) and mesenchymal stem cells (MSCs). Hematopoiesis only occurs when these two …

Bone marrow–derived mesenchymal stromal/stem cells (MSCs) are nonhematopoietic cells
that are able to differentiate into osteoblasts, adipocytes, and chondrocytes. In addition, they …

Adult stem cells are a promising cell source for cartilage regeneration. Unfortunately, due to
donor age and ex vivo expansion, stem cell senescence becomes a huge hurdle for these …