Current state and challenges in developing oral vaccines

JEV Ramirez, LA Sharpe, NA Peppas - Advanced drug delivery reviews, 2017 - Elsevier
While vaccination remains the most cost effective strategy for disease prevention,
communicable diseases persist as the second leading cause of death worldwide. There is a …

Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome

Y Lee, N Kamada, JJ Moon - Advanced drug delivery reviews, 2021 - Elsevier
The gastrointestinal tract (GIT) affects not only local diseases in the GIT but also various
systemic diseases. Factors that can affect the health and disease of both GIT and the human …

Mucosal immunity and vaccines

J Holmgren, C Czerkinsky - Nature medicine, 2005 - nature.com
There is currently great interest in developing mucosal vaccines against a variety of
microbial pathogens. Mucosally induced tolerance also seems to be a promising form of …

New horizons in adjuvants for vaccine development

SG Reed, S Bertholet, RN Coler, M Friede - Trends in immunology, 2009 - cell.com
Over the last decade, there has been a flurry of research on adjuvants for vaccines, and
several novel adjuvants are now in licensed products or in late stage clinical development …

Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA

J Holmgren, J Adamsson, F Anjuère, J Clemens… - Immunology letters, 2005 - Elsevier
Mucosal immunisation may be used both to protect the mucosal surfaces against infections
and as a means for immunological treatment of peripheral immunopathological disorders …

Mucosal delivery of vaccine antigens and its advantages in pediatrics

MT De Magistris - Advanced drug delivery reviews, 2006 - Elsevier
The delivery of vaccines through the mucosal route is very practical, non-invasive and
efficacious for the induction of mucosal and systemic immune responses. Appropriately …

Vaccine adjuvants: a priority for vaccine research

AM Harandi, D Medaglini, RJ Shattock… - Vaccine, 2010 - Elsevier
The workshop on vaccine adjuvants was held in July of 2009 at the European Commission
in Brussels, with the goal of identifying key scientific priorities as they pertain to the …

Crossing the barrier: Targeting epithelial receptors for enhanced oral vaccine delivery

B Devriendt, BG De Geest, BM Goddeeris… - Journal of controlled …, 2012 - Elsevier
Vaccination is the most efficient way to combat and prevent infectious diseases. However,
most vaccines are administered systemically and are ineffective in eliciting protective …

Vaccine adjuvants: key tools for innovative vaccine design

P Riese, K Schulze, T Ebensen… - Current topics in …, 2013 - benthamdirect.com
Vaccines represent the most efficient tool for preventing diseases caused by infectious
pathogens. During the last century significant progress has been made in vaccine …

Applications and optimization of immunization procedures

MK Schunk, GE Macallum - ILAR journal, 2005 - academic.oup.com
Classical immunization protocols have produced an antibody-based humoral response that
is very effective against susceptible infectious diseases. Immunization introduces an …