Malaria is still a major public health problem in Brazil, with approximately 306 000 registered
cases in 2009, but it is estimated that in the early 1940s, around six million cases of malaria …

Plasmodium vivax infection, the predominant cause of malaria in Asia and Latin America,
affects~ 14 million individuals annually, with considerable adverse effects on wellbeing and …

Background Antigen-specific antibody-mediated immune responses play an important role
in natural protection against clinical malaria, but conflicting estimates of this association …

Although the importance of humoral immunity to malaria has been established, factors that
control antibody production are poorly understood. Follicular helper T cells (Tfh cells) are …

Plasmodium vivax remains an important cause of malaria in South America and the Asia-
Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been …

Plasmodium vivax is the most geographically widespread of the malaria parasites causing
human disease, yet it is comparatively understudied compared with Plasmodium falciparum …

Background Malaria is a life-threatening disease caused by protozoan parasite of genus
Plasmodium. Various antigenic proteins of Plasmodium are considered as the major targets …

The utilisation of serological surveillance methods for malaria has the potential to identify
individuals exposed to Plasmodium vivax, including asymptomatic carriers. However, the …

The Duffy binding protein of Plasmodium vivax (DBP) is a critical adhesion ligand that
participates in merozoite invasion of human Duffy-positive erythrocytes. A small outbreak of …

Background Progress towards the development of a malaria vaccine against Plasmodium
vivax, the most widely distributed human malaria parasite, will require a better …