Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Indiscriminate usage and mismanagement of chemicals in the agricultural and industrial
sectors have contaminated different environmental compartments. Exposure to these …

Abstract Indoleamine 2, 3 dioxygenase-1 (IDO1) catalyzes tryptophan-kynurenine
metabolism in many inflammatory and cancer diseases. Of note, acute inflammation that …

Abstract 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental
contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor …

We have previously shown that in response to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-
elicited NAFLD progression, central carbon, glutaminolysis, and serine/folate metabolism …

Human exposure to arsenic via drinking water is one of globally concerned health issues.
Oxidative stress is regarded as the denominator of arsenic-inducing toxicities. Therefore, to …

Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental
contaminant that induces the progression of steatosis to steatohepatitis with fibrosis in mice …

The environmental contaminant 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) induces
hepatic steatosis mediated by the aryl hydrocarbon receptor. To further characterize TCDD …

Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of
circadian clock regulators, however the impact on clock-controlled metabolism has not been …

Polycyclic aromatic hydrocarbon exposure accelerates the initiation and progression of lung
cancer through aryl hydrocarbon receptor (AHR) signaling. Metabolic reprogramming is a …