Regulatory T cells: the many faces of Foxp3
Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a
requisite role in the maintenance of immunological homeostasis and prevention of …
requisite role in the maintenance of immunological homeostasis and prevention of …
Regulatory T cells in allergic diseases
MN Rivas, TA Chatila - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
The pathogenesis of allergic diseases entails an ineffective tolerogenic immune response to
allergens. Regulatory T (Treg) cells play a key role in sustaining immune tolerance to …
allergens. Regulatory T (Treg) cells play a key role in sustaining immune tolerance to …
tTregs, pTregs, and iTregs: similarities and differences
EM Shevach, AM Thornton - Immunological reviews, 2014 - Wiley Online Library
Summary Foxp3+ T‐regulatory cells (Tregs) are primarily generated in the thymus (tTreg),
but also may be generated extrathymically at peripheral sites (pTreg), or induced in cell …
but also may be generated extrathymically at peripheral sites (pTreg), or induced in cell …
The immunosuppressive tumour network: myeloid‐derived suppressor cells, regulatory T cells and natural killer T cells
D Lindau, P Gielen, M Kroesen, P Wesseling… - …, 2013 - Wiley Online Library
Myeloid‐derived suppressor cells (MDSC) and regulatory T (Treg) cells are major
components of the immune suppressive tumour microenvironment (TME). Both cell types …
components of the immune suppressive tumour microenvironment (TME). Both cell types …
Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease
T Vaikunthanathan, E Landmann, DM Correa… - …, 2023 - thelancet.com
Background Dysregulated inflammatory responses and oxidative stress are key pathogenic
drivers of chronic inflammatory diseases such as liver cirrhosis (LC). Regulatory T cells …
drivers of chronic inflammatory diseases such as liver cirrhosis (LC). Regulatory T cells …
Helios+ and Helios− Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires
AM Thornton, J Lu, PE Korty, YC Kim… - European journal of …, 2019 - Wiley Online Library
The transcription factor Helios is expressed in a large subset of Foxp3+ Tregs. We
previously proposed that Helios is a marker of thymic derived Treg (tTreg), while Helios …
previously proposed that Helios is a marker of thymic derived Treg (tTreg), while Helios …
Immunomodulatory effects of flavonoids: possible induction of T CD4+ regulatory cells through suppression of mTOR pathway signaling activity
A Hosseinzade, O Sadeghi… - Frontiers in …, 2019 - frontiersin.org
The increasing rate of autoimmune disorders and cancer in recent years has been a
controversial issue in all aspects of prevention, diagnosis, prognosis and treatment. Among …
controversial issue in all aspects of prevention, diagnosis, prognosis and treatment. Among …
Regulatory T cells in systemic lupus erythematosus
K Ohl, K Tenbrock - European journal of immunology, 2015 - Wiley Online Library
Systemic lupus erythematosus (SLE), an autoimmune disease, develops when immunologic
self‐tolerance fails. Treg cells are a subset of CD4+ T cells that maintain self‐tolerance by …
self‐tolerance fails. Treg cells are a subset of CD4+ T cells that maintain self‐tolerance by …
Foxp3+ T Regulatory Cells: Still Many Unanswered Questions—A Perspective After 20 Years of Study
EM Shevach - Frontiers in immunology, 2018 - frontiersin.org
T regulatory (Treg) cells were discovered more than 20 years ago and have remained a
topic of intense investigation by immunologists. The initial doubts about their existence were …
topic of intense investigation by immunologists. The initial doubts about their existence were …
Helios+ and Helios− cells coexist within the natural FOXP3+ T regulatory cell subset in humans
ME Himmel, KG MacDonald, RV Garcia… - The Journal of …, 2013 - journals.aai.org
FOXP3-expressing T regulatory cells (Tregs) can be divided into two distinct subsets:
naturally occurring Tregs (nTregs) that develop in the thymus, and induced Tregs (iTregs) …
naturally occurring Tregs (nTregs) that develop in the thymus, and induced Tregs (iTregs) …