Reduced hepatic synthesis of calcidiol in uremia
J Michaud, J Naud, D Ouimet, C Demers… - Journal of the …, 2010 - journals.lww.com
Calcidiol insufficiency is highly prevalent in chronic kidney disease (CKD), but the reasons
for this are incompletely understood. CKD associates with a decrease in liver cytochrome …
for this are incompletely understood. CKD associates with a decrease in liver cytochrome …
[HTML][HTML] Rapamycin prevents endothelial cell migration by inhibiting the endothelial-to-mesenchymal transition and matrix metalloproteinase-2 and-9: an in vitro study
H Gao, J Zhang, T Liu, W Shi - Molecular Vision, 2011 - ncbi.nlm.nih.gov
Purpose To evaluate the influence of rapamycin on endothelial-mesenchymal transition and
matrix metalloproteinase (MMP) secretion by human umbilical vein endothelial cell line EA …
matrix metalloproteinase (MMP) secretion by human umbilical vein endothelial cell line EA …
In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene
WR Swindell, MM Masternak, A Bartke - Experimental gerontology, 2010 - Elsevier
Mice lacking the pregnancy-associated plasma protein A (PappA) gene exhibit diminished
localized IGF-1 bioavailability and a 30% increase in mean life span. However, it is …
localized IGF-1 bioavailability and a 30% increase in mean life span. However, it is …
[HTML][HTML] HIV-associated nephropathy: role of mammalian target of rapamycin pathway
Both glomerular and tubular lesions are characterized by a proliferative phenotype in HIV-
associated nephropathy. We hypothesized that mammalian target of rapamycin (mTOR) …
associated nephropathy. We hypothesized that mammalian target of rapamycin (mTOR) …
Tetrahydrohyperforin prevents articular cartilage degeneration and affects autophagy in rats with osteoarthritis
J Zhang, S Wang, G Rong… - Experimental and …, 2018 - spandidos-publications.com
Osteoarthritis (OA) is a highly prevalent disease, which is associated with extracellular
matrix degradation and cell death in articular cartilage. The aim of the present study was to …
matrix degradation and cell death in articular cartilage. The aim of the present study was to …
Up-regulated mTOR pathway indicates active disease in both human native and transplant kidneys
W Li, PL Zhang - Annals of Clinical & Laboratory Science, 2013 - Assoc Clin Scientists
Background Recent studies show that up-regulated mammalian target of rapamycin (mTOR)
indicates cellular repair and senescence, possibly through interaction with reactive oxygen …
indicates cellular repair and senescence, possibly through interaction with reactive oxygen …
Reduction of Slit Diaphragm-associated Molecules by Sirolimus: Is it Enough to Induce Proteinuria?
BS Kim, JG Lee, Y Cho, SH Song, KH Huh… - Transplantation …, 2017 - Elsevier
Sirolimus (SRL), a mammalian target of rapamycin inhibitor, is widely used in
transplantation, but the mechanisms whereby it induces adverse effects, such as proteinuria …
transplantation, but the mechanisms whereby it induces adverse effects, such as proteinuria …
Effects of sirolimus on human mesangial cells
C Esposito, R Valentino, L Villa, N Serpieri… - Transplantation …, 2010 - Elsevier
Mesangial cell (MC) proliferation and production of extracellular matrix or loss of MC are
both central findings in a number of renal proteinuric diseases. However, the role of MC as …
both central findings in a number of renal proteinuric diseases. However, the role of MC as …
Comparative proteomic analysis of rapamycin versus cyclosporine combination treatment in mouse podocytes
Background The mechanism of podocyte injury observed with the use of rapamycin (RPM)
remains unclear. The conversion from calcineurin inhibitors (CNIs) to RPM in kidney …
remains unclear. The conversion from calcineurin inhibitors (CNIs) to RPM in kidney …
[PDF][PDF] 雷帕霉素在慢性肾脏病治疗中的应用研究
陈国纯， 刘伏友 - 中华肾脏病杂志, 2012 - cjn.org.cn
增高[18], 提示mTOR 的异常活化参与了DN 的发病过程, 动物实验证实雷帕霉素能够抑制STZ
糖尿病大鼠肾脏组织mTOR 通路的活化, 减轻DN 肾小球肥大等早期病理改变 …
糖尿病大鼠肾脏组织mTOR 通路的活化, 减轻DN 肾小球肥大等早期病理改变 …