[HTML][HTML] Endoplasmic reticulum stress activates unfolded protein response signaling and mediates inflammation, obesity, and cardiac dysfunction: therapeutic and …

OM Amen, SD Sarker, R Ghildyal, A Arya - Frontiers in pharmacology, 2019 - frontiersin.org
Obesity has been implicated as a risk factor for insulin resistance and cardiovascular
diseases (CVDs). Although the association between obesity and CVD is a well-established …

Ethnobotany, Chemistry, and Biological Activities of the Genus Tithonia (Asteraceae)

DA Chagas‐Paula, RB Oliveira, BA Rocha… - Chemistry & …, 2012 - Wiley Online Library
The genus Tithonia is an important source of diverse natural products, particularly
sesquiterpene lactones, diterpenes, and flavonoids. The collected information in this review …

The antioxidant effect of β-caryophyllene protects rat liver from carbon tetrachloride-induced fibrosis by inhibiting hepatic stellate cell activation

MA Calleja, JM Vieites, T Montero-Meterdez… - British journal of …, 2013 - cambridge.org
Plant-based whole foods provide thousands of bioactive metabolites to the human diet that
reduce the risk of developing chronic diseases. β-Caryophyllene (CAR) is a common …

Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells

CX Liu, QQ Yin, HC Zhou, YL Wu, JX Pu, L Xia… - Nature chemical …, 2012 - nature.com
Peroxiredoxins (Prxs) are potential therapeutic targets for major diseases such as cancers.
However, isotype-specific inhibitors remain to be developed. We report that adenanthin, a …

[HTML][HTML] Antimicrobial and antibiofilm action of casbane diterpene from Croton nepetaefolius against oral bacteria

NC Sa, TTA Cavalcante, AX Araujo, HS dos Santos… - Archives of oral …, 2012 - Elsevier
OBJECTIVE: The antibacterial activity of Casbane Diterpene (CD) was evaluated in vitro
against Streptococcus oralis, S. mutans, S. salivarius, S. sobrinus, S. mitis and S. sanguinis …

[HTML][HTML] Hypotensive action of naturally occurring diterpenes: a therapeutic promise for the treatment of hypertension

CR Tirapelli, SR Ambrosio, AM de Oliveira, RC Tostes - Fitoterapia, 2010 - Elsevier
Plants have always been an exemplary source of drugs and many of the currently available
medicines have been directly or indirectly derived from them. For this reason, the research …

Inhibition of angiotensin converting enzyme, angiotensin II receptor blocking, and blood pressure lowering bioactivity across plant families

GS Patten, MY Abeywardena… - Critical Reviews in Food …, 2016 - Taylor & Francis
Hypertension is a major risk factor for coronary heart disease, kidney disease, and stroke.
Interest in medicinal or nutraceutical plant bioactives to reduce hypertension has increased …

Leonuketal, a Spiroketal Diterpenoid from Leonurus japonicus

L Xiong, QM Zhou, Y Zou, MH Chen, L Guo… - Organic …, 2015 - ACS Publications
An architecturally complex spiroketal diterpenoid, leonuketal (1), was isolated from the aerial
parts of the plant Leonurus japonicus. This compound possessed an unprecedented …

[HTML][HTML] Identification of Coumarins and Antimicrobial Potential of Ethanolic Extracts of Dipteryx odorata and Dipteryx punctata

BCM Sousa, SP Castro, KA Lourido, AAM Kasper… - Molecules, 2022 - mdpi.com
Dipteryx odorata and Dipteryx punctata are species native to the Amazonian, traded by
extractivists to obtain coumarin. We aimed to analyze the presence of coumarin in the …

Lignans: Chemical and biological properties

WR Cunha, MLA Silva, RCS Veneziani… - … -A global perspective …, 2012 - books.google.com
The plant kingdom has formed the basis of folk medicine for thousands of years and
nowadays continues to provide an important source to discover new biologically active …