The past decade has seen tremendous advances in our understanding of the genetic factors
influencing response to a variety of drugs, including those targeted at treatment of …

Background Dermatologic surgeons will increasingly encounter patients on novel oral
antiplatelet and anticoagulant medications. Objectives We conducted a complete overview …

Vitamin K epoxide reductase (VKOR) drives the vitamin K cycle, activating vitamin K-
dependent blood clotting factors. VKOR is also the target of the widely used anticoagulant …

Objective: To systematically review evidence on genetic variants influencing outcomes
during warfarin therapy and provide practice recommendations addressing the key …

Introduction: Chronic kidney disease (CKD) is the progressive decline in renal function over
time. Patients with end-stage renal disease require renal replacement therapy such as …

As costs of next-generation sequencing decrease, identification of genetic variants has far
outpaced our ability to understand their functional consequences. This lack of understanding …

A systematic review and a meta‐analysis were performed to quantify the accumulated
information from genetic association studies investigating the impact of the CYP4F2 …

Background Warfarin is a widely used oral anticoagulant. Determining the correct dose
required to maintain the international normalised ratio (INR) within a therapeutic range can …

Despite the introduction of direct acting oral anticoagulants, warfarin remains the most
commonly prescribed oral anticoagulant. However, warfarin therapy is plagued by the large …

Background Vitamins play an essential role in various physiological and biological
processes, and their deficiency causes several health consequences in humans. Unlike …