The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …
devastating consequences. While the medical community has gained insight into the …
COVID-19 and multiorgan response
S Zaim, JH Chong, V Sankaranarayanan… - Current problems in …, 2020 - Elsevier
Since the outbreak and rapid spread of COVID-19 starting late December 2019, it has been
apparent that disease prognosis has largely been influenced by multiorgan involvement …
apparent that disease prognosis has largely been influenced by multiorgan involvement …
[HTML][HTML] Complex immune dysregulation in COVID-19 patients with severe respiratory failure
Proper management of COVID-19 mandates better understanding of disease pathogenesis.
The sudden clinical deterioration 7–8 days after initial symptom onset suggests that severe …
The sudden clinical deterioration 7–8 days after initial symptom onset suggests that severe …
COVID-19: consider cytokine storm syndromes and immunosuppression
As of March 12, 2020, coronavirus disease 2019 (COVID-19) has been con firmed in 125
048 people worldwide, carrying a mortality of approximately 3· 7%, 1 compared with a …
048 people worldwide, carrying a mortality of approximately 3· 7%, 1 compared with a …
Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)
Background The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting …
the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting …
Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines
A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in
the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; …
the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; …
Clinical criteria for COVID-19-associated hyperinflammatory syndrome: a cohort study
Background A subset of patients with COVID-19 develops a hyperinflammatory syndrome
that has similarities with other hyperinflammatory disorders. However, clinical criteria …
that has similarities with other hyperinflammatory disorders. However, clinical criteria …
Cardiovascular manifestations and treatment considerations in COVID-19
Since its recognition in December 2019, covid-19 has rapidly spread globally causing a
pandemic. Pre-existing comorbidities such as hypertension, diabetes, and cardiovascular …
pandemic. Pre-existing comorbidities such as hypertension, diabetes, and cardiovascular …
Recommendations for the management of hemophagocytic lymphohistiocytosis in adults
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
Immune effector cell–associated hematotoxicity: EHA/EBMT consensus grading and best practice recommendations
Hematological toxicity is the most common adverse event after chimeric antigen receptor
(CAR) T-cell therapy. Cytopenias can be profound and long-lasting and can predispose for …
(CAR) T-cell therapy. Cytopenias can be profound and long-lasting and can predispose for …