Feature attributions based on the Shapley value are popular for explaining machine
learning models. However, their estimation is complex from both theoretical and …

Serpins are a superfamily of proteins characterized by their common function as serine
protease inhibitors. So far, 36 serpins from nine clades have been identified. These proteins …

Local feature attribution methods are increasingly used to explain complex machine
learning models. However, current methods are limited because they are extremely …

SERPINA3, also called α-1-antichymotrypsin (AACT, ACT), is one of the inhibitors of serine
proteases, one of which is cathepsin G. As an acute-phase protein secreted into the plasma …

Abstract SERine Protease INhibitor clade A member 3 (SERPINA3), a member of the
SERine-Protease INhibitor (SERPIN) superfamily, principally works as a protease inhibitor in …

Serpins represent the most broadly distributed superfamily of proteases inhibitors. They
contribute to a variety of physiological functions and any alteration of the serpin-protease …

Selective vulnerability is an enigmatic feature of neurodegenerative diseases (NDs),
whereby a widely expressed protein causes lesions in specific cell types and brain regions …

Trimethyltin chloride (TMT) is a potent neurotoxin that causes neuroinflammation and
neuronal cell death. Melatonin is a well‐known anti‐inflammatory agent with significant …

Chronic neuroinflammation is recognized as a major neuropathological hallmark in a broad
spectrum of neurodegenerative diseases including Alzheimer's, Parkinson's, Frontal …

Exosomes are small extracellular vesicles (EVs) present in human biofluids that can
transport specific disease-associated molecules. Consequently blood-derived exosomes …