Neuroinflammation in Parkinson's disease and its potential as therapeutic target

Q Wang, Y Liu, J Zhou - Translational neurodegeneration, 2015 - Springer
Abstract Parkinson's disease (PD), the second most common age-associated
neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and …

Inflammation as a causative factor in the aetiology of Parkinson's disease

PS Whitton - British journal of pharmacology, 2007 - Wiley Online Library
Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting mainly the
elderly, although a small proportion of PD patients develop the illness at a much younger …

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

LM Collins, A Toulouse, TJ Connor, YM Nolan - Neuropharmacology, 2012 - Elsevier
Idiopathic Parkinson's disease (PD) represents a complex interaction between the inherent
vulnerability of the nigrostriatal dopaminergic system, a possible genetic predisposition, and …

A story of the potential effect of non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson's disease: beneficial or detrimental effects

M Alrouji, HM Al-Kuraishy, AI Al-Gareeb, HM Saad… - …, 2023 - Springer
Parkinson's disease (PD) is an advanced neurodegenerative disease (NDD) caused by the
degeneration of dopaminergic neurons (DNs) in the substantia nigra (SN). As PD is an age …

The influence of microglia on the pathogenesis of Parkinson's disease

CM Long-Smith, AM Sullivan, YM Nolan - Progress in neurobiology, 2009 - Elsevier
Parkinson's disease (PD) is characterised by degeneration of dopaminergic neurons in the
substantia nigra pars compacta (SNpc). Inflammation may be associated with the …

Highly reactive oxygen species: detection, formation, and possible functions

W Freinbichler, MA Colivicchi, C Stefanini… - Cellular and molecular …, 2011 - Springer
The so-called reactive oxygen species (ROS) are defined as oxygen-containing species that
are more reactive than O 2 itself, which include hydrogen peroxide and superoxide …

Protective mechanisms of flavonoids in Parkinson's disease

KB Magalingam, AK Radhakrishnan… - Oxidative medicine …, 2015 - Wiley Online Library
Parkinson's disease is a chronic, debilitating neurodegenerative movement disorder
characterized by progressive degeneration of dopaminergic neurons in the substantia nigra …

Non-steroidal anti-inflammatory drugs in Parkinson's disease

E Esposito, V Di Matteo, A Benigno, M Pierucci… - Experimental …, 2007 - Elsevier
Parkinson's disease (PD) is known to be a chronic and progressive neurodegenerative
disease caused by a selective degeneration of dopaminergic (DAergic) neurons in the …

The promise of neuroprotective agents in Parkinson's disease

SE Seidl, JA Potashkin - Frontiers in neurology, 2011 - frontiersin.org
Parkinson's disease (PD) is characterized by loss of dopamine neurons in the substantia
nigra of the brain. Since there are limited treatment options for PD, neuroprotective agents …

5-(3, 4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1, 2, 4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute …

LL Xu, YF Wu, F Yan, CC Li, Z Dai, QD You… - Free Radical Biology …, 2019 - Elsevier
Parkinson's disease (PD) is the second most common aging-related neurodegenerative
disease worldwide. Oxidative stress and neuroinflammation are critical events in the …