A proteoform is a defined form of a protein derived from a given gene with a specific amino
acid sequence and localized post‐translational modifications. In top‐down proteomic …

Beyond the genetic code, the human proteome is greatly diversified by genetic variations,
alternative splicing of RNA transcripts, and post-translational modifications (PTMs). 6, 7 In …

It is important to assess the identity and purity of proteins and protein complexes during and
after protein purification to ensure that samples are of sufficient quality for further …

Protein complexes exhibit great diversity in protein membership, post-translational
modifications and noncovalent cofactors, enabling them to function as the actuators of many …

Biological mass spectrometry (MS) encompasses a range of methods for characterizing
proteins and other biomolecules. MS is uniquely powerful for the structural analysis of …

Progress in structural biology research has led to a high demand for powerful and yet
complementary analytical tools for structural characterization of proteins and protein …

Multiple sclerosis (MS) is the inflammatory demyelinating and neurodegenerative disease of
the central nervous system (CNS) that affects approximately 2.8 million people worldwide. In …

With an overarching goal of characterizing the structure of every protein within a cell,
identifying its interacting partners, and quantifying the dynamics of the states in which it …

Top‐down proteomics is emerging as a preferred approach to investigate biological
systems, with objectives ranging from the detailed assessment of a single protein …

Native mass spectrometry (MS) is a rapidly advancing field in the analysis of proteins,
protein complexes, and macromolecular species of various types. The majority of native MS …