Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …

The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Centralized pain syndromes are associated with changes within the central nervous system
that amplify peripheral input and/or generate the perception of pain in the absence of a …

Abstract The Transient Receptor Potential Ankyrin 1 channel (TRPA1), is a member of the
large TRP family of ion channels, and functions as a Ca 2+ permeable non-selective cation …

Preclinical research has recently uncovered new molecular mechanisms underlying the
generation and transduction of pain, many of which represent opportunities for …

TRPA1 is a unique sensor of noxious stimuli and, hence, a potential drug target for
analgesics. Here we show that the antinociceptive effects of spinal and systemic …

Platinum-based anticancer drugs cause neurotoxicity. In particular, oxaliplatin produces
early-developing, painful, and cold-exacerbated paresthesias. However, the mechanism …

The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …

The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of
channels, is primarily localized to a subpopulation of primary sensory neurons of the …