Fungi have proved to be a rich and important source of a huge number of secondary
metabolites with a large variety of chemical structures and diverse biological activities …

Breast cancer is the most common cancer and the second leading cause of cancer death in
American women. It was the second most common cancer in the world in 2002, with more …

DNA double-strand breaks (DSBs) can lead to the development of genomic rearrangements,
which are hallmarks of cancer. Fusions between TMPRSS2, encoding the transmembrane …

Camptothecin (CPT) class of compounds has been demonstrated to be effective against a
broad spectrum of tumors. Their molecular target has been firmly established to be human …

A number of DNA minor groove-binding ligands (MGBLs) are known to exhibit antitumor and
antimicrobial activities. We show that DNA topoisomerase (Topo) I may be a …

Camptothecin is a plant alkaloid extract from the Camptotheca acumminata tree, which is
cultivated throughout Asia (1). In the early 197Os, camptothecin demonstrated antineoplastic …

Etoposide is an antitumor agent currently in clinical use for the treatment of small cell lung
cancer, testicular cancer and lymphomas. Since the introduction of etoposide in 1971, its …

The camptothecins are a new class of chemotherapeutic agents which have a novel
mechanism of action targeting the nuclear enzyme topoisomerase I. Knowledge of the …

Topological relationships inDNA such as over/underwinding, knotting, or tangling profoundly
influence the cellular functions of the genetic material (1). Conse-quently, it is not surprising …

Cell cycle arrest in G2 phase is a common response to a variety of DNA-damaging agents.
The coupling between DNA damage and G2 arrest was studied in synchronized HeLa cells …