Experiments in the life sciences often involve tools from a variety of domains such as mass
spectrometry, next generation sequencing, or image processing. Passing the data between …

The successes of antitumor immuno-based therapies and the application of next-generation
sequencing to mutation profiling have produced insights into the specific targets of antitumor …

Personalized multipeptide vaccines are currently being discussed intensively for tumor
immunotherapy. In order to identify epitopes—short, immunogenic peptides—suitable for …

T-cell-based immunotherapies hold tremendous potential in the fight against cancer, thanks
to their capacity to specifically targeting diseased cells. Nevertheless, this potential has been …

Motivation Breast cancer is the second leading cause of cancer death among women.
Tumors, even of the same histopathological subtype, exhibit a high genotypic diversity that …

The immunopeptidome corresponds to the repertoire of peptides presented at the cell
surface by the major histocompatibility complex (MHC) molecules. Cytotoxic T cells scan this …

Cancer immunotherapy has now been conclusively shown to be capable of producing
durable responses for a substantial number of patients. Adoptive cell transfer and …

Bioinformatics is an interdisciplinary field that integrates the knowledge of computer science,
mathematics, and physics into biology. Automated methods for genome sequencing …

Cancer genome sequencing is useful for diagnosis and personalized treatment. Analysis of
the sequencing data involves integration of computation, statistics and system biology …

Background Multi-epitope vaccines have become the preferred strategy for protection
against infectious diseases by integrating multiple MHC-restricted T-cell and B-cell epitopes …