The anthracycline drug doxorubicin is among the most used—and useful—
chemotherapeutics. While doxorubicin is highly effective in the treatment of various …

The recent shift in sociopolitical debates and growing liberalization of cannabis use across
the globe has raised concern regarding its impact on vulnerable populations, such as …

Histone lysine methylation, mediated by mixed-lineage leukemia (MLL) proteins, is now
known to be critical in the regulation of gene expression, genomic stability, cell cycle and …

Epigenetic mechanisms, which include DNA methylation, a variety of post-translational
modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination …

Epigenetic modifications such as histone methylation permit change in chromatin structure
without accompanying change in the underlying genomic sequence. A number of studies in …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …

Mutations in one SETD5 allele are genetic causes of intellectual disability and autistic
spectrum disorders. However, the mechanisms by which SETD5 regulates brain …

To understand how diversity is distributed in space is a fundamental aim for optimizing future
species and community conservation. We examined in parallel species richness and beta …

Neuronal circuits within the prefrontal cortex (PFC) mediate higher cognitive functions and
emotional regulation that are disrupted in psychiatric disorders. The PFC undergoes …