[HTML][HTML] Control of DNA replication timing in the 3D genome
The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
H3K9me3-dependent heterochromatin: barrier to cell fate changes
Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
[HTML][HTML] Multiscale 3D genome rewiring during mouse neural development
Chromosome conformation capture technologies have revealed important insights into
genome folding. Yet, how spatial genome architecture is related to gene expression and cell …
genome folding. Yet, how spatial genome architecture is related to gene expression and cell …
Topologically associating domains are stable units of replication-timing regulation
Eukaryotic chromosomes replicate in a temporal order known as the replication-timing
program. In mammals, replication timing is cell-type-specific with at least half the genome …
program. In mammals, replication timing is cell-type-specific with at least half the genome …
DNA replication origin activation in space and time
M Fragkos, O Ganier, P Coulombe… - Nature reviews Molecular …, 2015 - nature.com
DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …
DNA methylation loss in late-replicating domains is linked to mitotic cell division
DNA methylation loss occurs frequently in cancer genomes, primarily within lamina-
associated, late-replicating regions termed partially methylated domains (PMDs). We …
associated, late-replicating regions termed partially methylated domains (PMDs). We …
[HTML][HTML] Topological domains in mammalian genomes identified by analysis of chromatin interactions
The spatial organization of the genome is intimately linked to its biological function, yet our
understanding of higher order genomic structure is coarse, fragmented and incomplete. In …
understanding of higher order genomic structure is coarse, fragmented and incomplete. In …
Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells
Single-cell epigenome sequencing techniques have recently been developed. However, the
combination of different layers of epigenome sequencing in an individual cell has not yet …
combination of different layers of epigenome sequencing in an individual cell has not yet …
dcHiC detects differential compartments across multiple Hi-C datasets
The compartmental organization of mammalian genomes and its changes play important
roles in distinct biological processes. Here, we introduce dcHiC, which utilizes a multivariate …
roles in distinct biological processes. Here, we introduce dcHiC, which utilizes a multivariate …
Differential DNA mismatch repair underlies mutation rate variation across the human genome
Cancer genome sequencing has revealed considerable variation in somatic mutation rates
across the human genome, with mutation rates elevated in heterochromatic late replicating …
across the human genome, with mutation rates elevated in heterochromatic late replicating …