Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …

Alzheimer's disease (AD) is the most common form of dementia, which is progressively
affecting elderly people. The dyshomeostasis of biometals and accumulation of toxic metals …

The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may
drive AD pathogenesis; however, the triggering factors and the period of their action are …

Lead occurs primarily in the inorganic form in the environment. Human exposure is mainly
via food and water, with some via air, dust and soil. In average adult consumers, lead dietary …

Lead (Pb) is a xenobiotic metal with no known essential function in cellular growth,
proliferation, or signaling. Decades of research characterizing the toxicology of Pb have …

Human serum albumin (HSA), being the most abundant carrier protein in blood and a
modern day clinical tool for drug delivery, attracts high attention among biologists. Hence, its …

Following the observation of increased oxidative DNA damage in nuclear and mitochondrial
DNA extracted from post-mortem brain regions of patients affected by neurodegenerative …

Alzheimer disease (AD) is a progressive neurodegenerative disorder whose clinical
manifestations appear in old age. The sporadic nature of 90% of AD cases, the differential …

With the increase in life expectancy registered in the past few decades, the prevalence of
various medical conditions related to aging has been observed, such as dementia and …

Beta-amyloid (Aβ) peptide is one of the main characteristic biomarkers of Alzheimer's
disease (AD). Previous clinical investigations have proposed that unusual concentrations of …