Low-energy electron damage to condensed-phase DNA and its constituents

Y Gao, Y Zheng, L Sanche - International Journal of Molecular Sciences, 2021 - mdpi.com
The complex physical and chemical reactions between the large number of low-energy (0–
30 eV) electrons (LEEs) released by high energy radiation interacting with genetic material …

The ups and downs of ectoine: structural enzymology of a major microbial stress protectant and versatile nutrient

L Hermann, CN Mais, L Czech, SHJ Smits… - Biological …, 2020 - degruyter.com
Ectoine and its derivative 5-hydroxyectoine are compatible solutes and chemical
chaperones widely synthesized by Bacteria and some Archaea as cytoprotectants during …

The MOUSE project: a meticulous approach for obtaining traceable, wide-range X-ray scattering information

GJ Smales, BR Pauw - Journal of instrumentation, 2021 - iopscience.iop.org
Herein, we provide a" systems architecture"-like overview and detailed discussions of the
methodological and instrumental components that, together, comprise the" MOUSE" project …

Highly efficient production of ectoine via an optimized combination of precursor metabolic modules in Escherichia coli BL21

S Xu, B Zhang, W Chen, K Ye, J Shen, P Liu, J Wu… - Bioresource …, 2023 - Elsevier
Ectoine is an osmotic pressure protectant observed in various microorganisms and is widely
used in cosmetics and pharmaceuticals. The market value of ectoine has increased …

[HTML][HTML] Apoptosis induction in human hepatoma cell line HepG2 cells by trans-Anethole via activation of mitochondria-mediated apoptotic pathways

S Harakeh, R Al-Raddadi, T Alamri, S Al-Jaouni… - Biomedicine & …, 2023 - Elsevier
Abstract trans-Anethole a valuable compound derived from star anise widely used by ethnic
tribals to manage numerous human diseases. In this study antiproliferative activities of trans …

Accessing radiation damage to biomolecules on the nanoscale by particle-scattering simulations

MB Hahn - Journal of Physics Communications, 2023 - iopscience.iop.org
Radiation damage to DNA plays a central role in radiation therapy to cure cancer. The
physico-chemical and biological processes involved encompass huge time and spatial …

What does ectoine do to DNA? A molecular-scale picture of compatible solute–biopolymer interactions

J Wittmar, S Meyer, T Sieling, J Kunte… - The Journal of …, 2020 - ACS Publications
Compatible solutes accumulate in the cytoplasm of halophilic microorganisms, enabling
their survival in a high-salinity environment. Ectoine is such a compatible solute. It is a …

[PDF][PDF] 相容溶质四氢嘧啶的微生物合成研究进展

张鑫, 舒志万, 李永臻, 邢江娃, 王嵘, 沈国平… - 生物工程 …, 2022 - researchgate.net
四氢嘧啶(ectoine) 作为一种氨基酸的衍生物, 是嗜盐微生物胞内重要的天然次级代谢物,
具有保护细胞和稳定生物大分子的功能, 可广泛应用于药物制备佐剂, 器官移植与保存 …

Combined cell and nanoparticle models for TOPAS to study radiation dose enhancement in cell organelles

MB Hahn, JM Zutta Villate - Scientific Reports, 2021 - nature.com
Dose enhancement by gold nanoparticles (AuNP) increases the biological effectiveness of
radiation damage in biomolecules and tissue. To apply them effectively during cancer …

Study of osmoadaptation mechanisms of halophilic Halomonas alkaliphila XH26 under salt stress by transcriptome and ectoine analysis

T Zhang, X Zhang, Y Li, N Yang, L Qiao, Z Miao, J Xing… - Extremophiles, 2022 - Springer
Halophilic bacteria such as the genus Halomonas are promising candidates in diverse
industrial, agricultural and biomedical applications. Here, we successfully isolated a …