This article provides a perspective on major innovations over the past century in research on
the spinal cord and, specifically, on specialized spinal circuits involved in the control of …

Over the past 40 years, much has been learned about the role of serotonin in spinal cord
reflex modulation and locomotor pattern generation. This review presents an historical …

Central pattern generators (CPGs) are generally defined as networks of neurons capable of
enabling the production of central commands, specifically controlling stereotyped, rhythmic …

We examined the ability of the isolated lumbosacral spinal cord of the neonatal mouse (P0–
7) to generate rhythmic motor activity under several different conditions. In the absence of …

The intrinsic properties of mammalian spinal motoneurons provide them with the capability
to produce high rates of sustained firing in response to transient inputs (bistability). Even …

Rhythm generation in neuronal networks relies on synaptic interactions and pacemaker
properties. Little is known about the contribution of the latter mechanisms to the integrated …

Coordination of neuronal activity to produce movement is generally thought to depend on
spike activity in premotor interneuronal networks. Here we show that even without such …

Locomotion is a complex motor task generated by spinal circuits driving motoneurons in a
precise sequence to control the timing and vigor of movements, but the underlying circuit …

In flies, neuronal sensors detect prandial changes in circulating fructose levels and either
sustain or terminate feeding, depending on internal state. Here, we describe a three-part …

In order for locomotion to occur, a complex pattern of muscle activation is required. For more
than a century, it has been known that the timing and pattern of stepping movements in …