Unusual amino acids are fundamental building blocks of modern medicinal chemistry. The
combination of readily functionalized amine and carboxyl groups attached to a chiral central …

Marine sponges and tunicates, fungi, bacteria, and other lower animal forms are rich
sources of structurally unusual, biologically active peptides. 1, 2 These peptides exhibit a …

The largely unexplored marine world that presumably harbors the most biodiversity may be
the vastest resource to discover novel 'validated'structures with novel modes of action that …

Marine organisms represent a valuable source of new compounds. The biodiversity of the
marine environment and the associated chemical diversity constitute a practically unlimited …

The oceans are a uniquely rich source of bioactive metabolites, of which sponges have
been shown to be among the most prolific producers of diverse bioactive secondary …

Bicyclic peptides have greater conformational rigidity and metabolic stability than linear and
monocyclic peptides and are capable of binding to challenging drug targets with antibody …

Oceanic environments are one of the largest sources of bioactive molecules, due to the high
degree of biodiversity and the innumerable ecological relationships established between …

We present a yeast chemical-genomics approach designed to identify genes that when
mutated confer drug resistance, thereby providing insight about the modes of action of …

Marine natural products represent novel and diverse chemotypes that serve as templates for
the discovery and development of therapeutic agents with distinct mechanisms of action …

Antimicrobial peptides are widely expressed in organisms and have been linked to innate
and acquired immunities in vertebrates. These compounds are constitutively expressed and …