Hemorrhage is the leading cause of preventable death in combat trauma and the secondary
cause of death in civilian trauma. A significant number of deaths due to hemorrhage occur …

Uncontrolled bleeding is a major problem in trauma and emergency medicine. While
materials for trauma applications would certainly find utility in traditional surgical settings, the …

Treatment of bleeding disorders using transfusion of donor-derived platelets faces logistical
challenges due to their limited availability, high risk of contamination, and short (5 to 7 days) …

Platelets are anucleate cell‐fragments derived predominantly from megakaryocytes in the
bone marrow and released in the blood circulation, with a normal count of 150 000–40 000 …

For rapid and effective hemostasis of uncontrollable bleeding, versatile hemostatic agents
have been emerging. Among them, polyphenol-derived adhesives have attracted those …

Platelet derived bio-products in the form of platelet rich plasma, plasma rich in growth
factors, or plasma-free platelet releasates, are being studied worldwide with the aim of …

The lack of innovation in von Willebrand disease (VWD) originates from many factors
including the complexity and heterogeneity of the disease but also from a lack of recognition …

Platelets are damage sentinels of the intravascular compartment, initiating and coordinating
the primary response to tissue injury. Severe trauma and hemorrhage induce profound …

Platelets are anucleate blood cells produced from megakaryocytes predominantly in the
bone marrow and released into blood circulation at a healthy count of 150,000–400, 00 per …

Improvements have been made in optimizing initial care of trauma patients, both in
prehospital systems as well as in the emergency department, and these have also favorably …