Treslin, a TopBP1-interacting protein, is necessary for deoxyribonucleic acid (DNA)
replication in vertebrates. Association between Treslin and TopBP1 requires cyclin …

Background The initiation of DNA replication is a very important and highly regulated step in
the cell division cycle. It is of interest to compare different groups of eukaryotic organisms (a) …

S-phase cyclin-dependent kinases (CDKs) stimulate replication initiation and accelerate
progression through the replication timing program, but it is unknown which CDK substrates …

Faithful duplication of the genome in eukaryotes requires ordered assembly of a multi-
protein complex called the pre-replicative complex (pre-RC) prior to S phase; transition to …

Cyclin-dependent kinase (CDK) plays a vital role in proliferation control across eukaryotes.
Despite this, how CDK mediates cell cycle and developmental transitions in metazoa is …

Abstract Dbf4-dependent kinase (DDK) and cyclin-dependent kinase (CDK) are essential to
initiate DNA replication at individual origins. During replication stress, the S-phase …

Since the discovery of the Forkhead-associated (FHA) domain in 1995, research groups
have pursued the characterization of FHA domains and the interactions that they regulate …

A key step in the initiation of eukaryotic DNA replication is the binding of the activator protein
Cdc45 to promote MCM helicase unwinding of the origin template. We show here that the c …

Aberrant DNA replication, including over-replication or under-replication may lead to life-
threatening mutation or even cause human diseases. This thesis focused on three issues …

CELLULAR EFFECTS OF REPLICATING A POLYPURINE-POLYPYRIMIDINE SEQUENCE
AND THE INTERACTIONS OF DUE-B WITH REPLICATION PROTEINS Page 1 CELLULAR …