Structure-function relationship of tear film lipid layer: A contemporary perspective

GA Georgiev, P Eftimov, N Yokoi - Experimental eye research, 2017 - Elsevier
Tear film lipid layer (TFLL) stabilizes the air/tear surface of the human eye. Meibomian gland
dysfunction (MGD) resulting in quantitative and qualitative modifications of TFLL major (> …

Lipid conformational order and the etiology of cataract and dry eye

D Borchman - Journal of lipid research, 2021 - ASBMB
Lens and tear film lipids are as unique as the systems they reside in. The major lipid of the
human lens is dihydrosphingomylein, found in quantity only in the lens. The lens contains a …

Human meibum cholesteryl and wax ester variability with age, sex, and meibomian gland dysfunction

D Borchman, A Ramasubramanian… - … & Visual Science, 2019 - iovs.arvojournals.org
Purpose: Relationships between tear film lipid (TFL) layer composition, structure, and
function could provide insight into the etiology of dry eye. The molar ratio of cholesteryl ester …

Meibomian gland dysfunction clinical practice guidelines

S Amano, J Shimazaki, N Yokoi, Y Hori, R Arita… - Japanese Journal of …, 2023 - Springer
MRKC Meibomitis-related keratoconjunctivitis NIBUT Noninvasive breakup time of tear film
NMR Nuclear magnetic resonance oMGD Obstructive meibomian gland dysfunction OSDI …

Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis

GA Georgiev, MS Gh, J Romano, KLD Teixeira… - Journal of Biological …, 2021 - ASBMB
Lipids in complex, protein-enriched films at air/liquid interfaces reduce surface tension. In
the absence of this benefit, the light refracting and immunoprotective tear film on eyes would …

Surface chemistry interactions of cationorm with films by human meibum and tear film compounds

GA Georgiev, N Yokoi, Y Nencheva, N Peev… - International journal of …, 2017 - mdpi.com
Cationorm®(CN) cationic nanoemulsion was demonstrated to enhance tear film (TF) stability
in vivo possibly via effects on tear film lipid layer (TFLL). Therefore the interactions of CN …

Saturation of cholesteryl esters produced by human meibomian gland epithelial cells after treatment with rosiglitazone

JF Ziemanski, L Wilson, S Barnes, KK Nichols - The ocular surface, 2021 - Elsevier
Purpose The purpose of this study was to compare the cholesteryl ester (CE) profiles
expressed from human meibomian gland epithelial cells (HMGECs) in response to …

[HTML][HTML] Integrated multi-omics and machine learning approach reveals lipid metabolic biomarkers and signaling in age-related meibomian gland dysfunction

Y Cai, S Zhang, L Chen, Y Fu - Computational and Structural Biotechnology …, 2023 - Elsevier
Meibomian gland dysfunction (MGD) is a prevalent inflammatory disorder of the ocular
surface that significantly impacts patients' vision and quality of life. The underlying …

Candidate molecular compounds as potential indicators for meibomian gland dysfunction

K Asiedu - Frontiers in Medicine, 2022 - frontiersin.org
Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease throughout the
world. Studies have shown that several molecules in meibum, including but not limited to …

Morphology and volume of Meibomian glands ex vivo pre and post partial tarsal plate excision, cryotherapy and laser therapy in the dog using microCT

V Zwiauer‐Wolfbeisser, S Handschuh… - Veterinary …, 2023 - Wiley Online Library
Objective To determine the morphology and volume of Meibomian glands (MG) of dogs with
microCT before and after partial tarsal plate excision (PTPE), cryotherapy, and laser therapy …